Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy.
Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy.
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DOI：
10.3748/wjg.v23.i35.6437
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发表时间：
2017-09-21
影响因子：
4.3
通讯作者：
Kumita SI
中科院分区：
文献类型：
--
作者：
Miki I;Murata S;Uchiyama F;Yasui D;Ueda T;Sugihara F;Saito H;Yamaguchi H;Murakami R;Kawamoto C;Uchida E;Kumita SI
目的探讨原发性肝癌（HCC）发生部位与肝动脉化疗栓塞（TACE）疗效的关系。我们评价了2011年1月至2014年6月期间接受TACE治疗的115例患者（127个结节），不包括复发性结节。根据mRECIST评价TACE疗效。HCC位置系数计算为从中央门静脉部分到HCC中心的距离（mm）/多平面重建图像（MPR）上的肝脏直径（mm），以可视化门静脉和HCC中心的右支和左支的分叉。在Child-Pugh分级A和B级患者中，比较完全缓解（CR）组和非CR组的HCC位置系数。Child-Pugh分级A级患者中，CR组所有结节、右叶和内侧段中位HCC位置系数显著高于非CR组（分别为0.82 vs 0.62，P < 0.001; 0.71 vs 0.59，P < 0.01; 0.81 vs 0.49，P < 0.05）。CR组与非CR组外侧段肝癌的中位定位系数差异无统计学意义（0.67 vs 0.65，P > 0.05）。另一方面，在Child-Pugh分级为B的患者中，CR组和非CR组的每个叶和段的HCC中位位置系数没有显著差异。对于Child-Pugh A级患者的右叶外周区和内侧段HCC，TACE疗效可能会有所改善。
To evaluate the relationship between the location of hepatocellular carcinoma (HCC) and the efficacy of transarterial chemoembolization (TACE). We evaluated 115 patients (127 nodules), excluding recurrent nodules, treated with TACE between January 2011 and June 2014. TACE efficacy was evaluated according to mRECIST. The HCC location coefficient was calculated as the distance from the central portal portion to the HCC center (mm)/liver diameter (mm) on multiplanar reconstruction images rendered (MPR) to visualize bifurcation of the right and left branches of the portal vein and HCC center. The HCC location coefficient was compared between complete response (CR) and non-CR groups in Child-Pugh grade A and B patients. The median location coefficient of HCC among all nodules, the right lobe, and the medial segment was significantly higher in the CR group than in the non-CR group in the Child-Pugh grade A patients (0.82 vs 0.62, P < 0.001; 0.71 vs 0.59, P < 0.01; 0.81 vs 0.49, P < 0.05, respectively). However, there was no significant difference in the median location coefficient of the HCC in the lateral segment between in the CR and in the non-CR groups (0.67 vs 0.65, P > 0.05). On the other hand, in the Child-Pugh grade B patients, the HCC median location coefficient in each lobe and segment was not significantly different between in the CR and in the non-CR groups. Improved TACE efficacy may be obtained for HCC in the peripheral zone of the right lobe and the medial segment in Child-Pugh grade A patients.
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影响因子：
4.6
作者：
Kwan, Sharon W.;Fidelman, Nicholas;Yao, Francis Y.
通讯作者：
Yao, Francis Y.
影响因子：
13.5
作者：
Lo, CM;Ngan, H;Wong, J
通讯作者：
Wong, J
影响因子：
--
作者：
Okubo, Hironao;Mogami, Miwa;Watanabe, Sumio
通讯作者：
Watanabe, Sumio
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
6.3
作者：
Jacobsson, H;Jonas, E;Larsson, SA
通讯作者：
Larsson, SA