Feminizing cholinergic neurons in a male Drosophila nervous system enhances aggression.
Feminizing cholinergic neurons in a male Drosophila nervous system enhances aggression.
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作者：
Mundiyanapurath S;Chan YB;Leung AK;Kravitz EA
先前对果蝇的研究已经证明，果蝇是像雄性还是像雌性一样战斗，可以通过选择性地操纵雄性和雌性神经系统中的性别决定基因来转换。在这里，我们扩展这些研究表明，通过表达的Transformer基因改变雄性果蝇神经系统中的胆碱能神经元的性别增加了苍蝇的侵略水平，而不会改变苍蝇的战斗方式。与对照相比，以这种方式进行的Transformer操作不会改变突变雄性的趋光性、趋地性、运动性或气味回避。胆碱能神经元必须通过这一途径雌性化的晚期幼虫/早期蛹阶段的发展，以显示增强的侵略表型。其他研究者已经证明，这是同一时期，在此期间，性二型行为模式在苍蝇中被指定。在不同的无结果表达神经元簇中发现了不同数量的共表达无结果和胆碱乙酰转移酶的神经元：它们共同构成了大脑和神经索中无结果表达神经元的大约10%。
Previous studies in Drosophila have demonstrated that whether flies fight like males or females can be switched by selectively manipulating genes of the sex determination hierarchy in male and female nervous systems. Here we extend these studies by demonstrating that changing the sex of cholinergic neurons in male fruit fly nervous systems via expression of the transformer gene increases the levels of aggression shown by the flies without altering the way the flies fight. Transformer manipulation in this way does not change phototaxis, geotaxis, locomotion or odor avoidance of the mutant males compared to controls. Cholinergic neurons must be feminized via this route during the late larval/early pupal stages of development to show the enhanced aggression phenotype. Other investigators have shown that this is the same time period during which sexually dimorphic patterns of behavior are specified in flies. Neurons that co-express fruitless and choline acetyl transferase are found in varying numbers within different clusters of fruitless-expressing neurons: together they make up approximately 10% of the pool of fruitless-expressing neurons in the brain and nerve cord.
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影响因子：
2.5
作者：
HOFFMANN, AA
通讯作者：
HOFFMANN, AA
影响因子：
1.6
作者：
HADLER, NM
通讯作者：
HADLER, NM
DOI：
10.1073/pnas.082102599
发表时间：
2002-04-16
影响因子：
11.1
作者：
Chen, S;Lee, AY;Kravitz, EA
通讯作者：
Kravitz, EA
影响因子：
30.8
作者：
Dierick, Herman A.;Greenspan, Ralph J.
通讯作者：
Greenspan, Ralph J.
影响因子：
1.2
作者：
Salvaterra, Paul M.;Kitamoto, Toshihiro
通讯作者：
Kitamoto, Toshihiro