Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity.
Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity.
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DOI：
10.3389/fimmu.2016.00480
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发表时间：
2016
影响因子：
7.3
通讯作者：
Sanz L
中科院分区：
文献类型：
--
作者：
Navarro R;Compte M;Álvarez-Vallina L;Sanz L
周细胞(PC)是小血管内皮细胞周围的壁细胞。PC传统上被认为具有结构功能，是血管成熟和稳定所必需的。然而，越来越多的证据表明，PC也显示出免疫特性。它们可以对一系列促炎刺激做出反应，并能够感觉到不同类型的危险，这是因为它们表达了功能性的模式识别受体，有助于启动先天免疫反应。在此背景下，PC不仅能分泌多种趋化因子，还能高表达ICAM-1和VCAM-1等黏附分子，参与免疫细胞跨血管壁运输的调控。PC除了在先天免疫中发挥作用外，还参与获得性免疫。据报道，与PC的相互作用使T细胞丧失活力，这至少部分归因于PD-L1的表达。PC作为肿瘤微环境的组成部分，也可以调节抗肿瘤免疫反应。然而，它们的作用是复杂的，还需要进一步的研究来更好地了解PC与免疫细胞的相互作用，以便将它们视为潜在的治疗靶点。无论如何，从现在开始，免疫学家将以新的眼光看待PC。
Pericytes (PC) are mural cells that surround endothelial cells in small blood vessels. PC have traditionally been credited with structural functions, being essential for vessel maturation and stabilization. However, an accumulating body of evidence suggests that PC also display immune properties. They can respond to a series of pro-inflammatory stimuli and are able to sense different types of danger due to their expression of functional pattern-recognition receptors, contributing to the onset of innate immune responses. In this context, PC not only secrete a variety of chemokines but also overexpress adhesion molecules such as ICAM-1 and VCAM-1 involved in the control of immune cell trafficking across vessel walls. In addition to their role in innate immunity, PC are involved in adaptive immunity. It has been reported that interaction with PC anergizes T cells, which is attributed, at least in part, to the expression of PD-L1. As components of the tumor microenvironment, PC can also modulate the antitumor immune response. However, their role is complex, and further studies will be required to better understand the crosstalk of PC with immune cells in order to consider them as potential therapeutic targets. In any case, PC will be looked at with new eyes by immunologists from now on.
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