Sun exposure and risk of epithelial ovarian cancer.
Sun exposure and risk of epithelial ovarian cancer.
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日晒和上皮卵巢癌的风险。
DOI：
10.1007/s10552-012-0076-x
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发表时间：
2012-12
影响因子：
2.3
通讯作者：
Rossing, Mary Anne
中科院分区：
文献类型：
--
作者：
Bodelon, Clara;Cushing-Haugen, Kara L.;Wicklund, Kristine G.;Doherty, Jennifer A.;Rossing, Mary Anne
阳光照射（维生素 D 的主要来源）与卵巢癌风险之间的关联并不一致。此外，研究尚未调查人一生中不同时期的阳光照射是否会导致风险关联的差异，并且对于不同组织学亚型的差异知之甚少。我们对 2002 年至 2009 年间华盛顿州西部 1,334 名被诊断患有上皮性卵巢癌的非西班牙裔白人女性和 1,679 名非西班牙裔白人对照者进行了一项基于人群的病例对照研究，评估了上皮性卵巢癌与体质色素沉着特征、阳光暴露行为和基于居住史的紫外线 (UV) 暴露指数的关系。信息是通过面对面访谈收集的。 Logistic 回归用于计算优势比、95% 置信区间和趋势 P 值 (Ptrend)。我们注意到，无论是在一生中还是在特定的年龄间隔内，与基于居住地的紫外线暴露测量或自我报告的阳光暴露没有关联。此外，我们几乎没有观察到体质色素沉着特征与风险之间存在关联的证据，除了报告称长期暴露在阳光下晒黑能力增强的女性风险增加的建议之外（Ptrend = 0.03）。这项研究的结果表明，阳光照射对上皮性卵巢癌的风险影响不大。可能还需要对日照梯度较大的人群进行更多研究。
Associations between sun exposure (a primary source of Vitamin D) and risk of ovarian cancer have been inconsistent. Furthermore, studies have not investigated whether sun exposure at different periods in the lifetime of a person results in differences in risk associations, and little is known about differences according to histological subtype. Using a population-based case-control study of 1,334 non-Hispanic white women diagnosed with epithelial ovarian cancer in western Washington State between 2002–2009 and 1,679 non-Hispanic white controls, we assessed the relation of epithelial ovarian cancer with constitutional pigmentation characteristics, sun exposure behaviors, and an index of ultraviolet (UV) exposure based on residential history. Information was collected through in-person interviews. Logistic regression was used to compute odds ratios, 95% confidence intervals and trend P values (Ptrend). We noted no association with residence-based measures of UV exposure or self-reported sun exposure, either over the lifetime or within specific age intervals. Also, we observed little evidence of association between constitutional pigmentation characteristics and risk, save for a suggestion of increased risk among women who reported increased ability to suntan upon prolonged sun exposure (Ptrend= 0.03). Results from this study suggest that sun exposure has little influence on the risk of epithelial ovarian cancer. Additional studies in populations with a wider gradient of sun exposure may yet be warranted.
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影响因子：
11.2
作者：
Tworoger SS;Gates MA;Lee IM;Buring JE;Titus-Ernstoff L;Cramer D;Hankinson SE
通讯作者：
Hankinson SE
影响因子：
3.8
作者：
John, Esther M.;Koo, Jocelyn;Schwartz, Gary G.
通讯作者：
Schwartz, Gary G.
DOI：
10.1093/jnci/djg075
发表时间：
2003-10-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Veierod, MB;Weiderpass, E;Adami, HO
通讯作者：
Adami, HO
DOI：
10.2215/cjn.01350308
发表时间：
2008-09-01
影响因子：
9.8
作者：
Holick, Michael F.
通讯作者：
Holick, Michael F.
影响因子：
3.7
作者：
WAKSBERG, J
通讯作者：
WAKSBERG, J