Evidence accumulation in obsessive-compulsive disorder: the role of uncertainty and monetary reward on perceptual decision-making thresholds.
Evidence accumulation in obsessive-compulsive disorder: the role of uncertainty and monetary reward on perceptual decision-making thresholds.
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DOI：
10.1038/npp.2014.303
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发表时间：
2015-03-13
影响因子：
7.6
通讯作者：
Voon, Valerie
中科院分区：
文献类型：
--
作者：
Banca, Paula;Vestergaard, Martin D.;Rankov, Vladan;Baek, Kwangyeol;Mitchell, Simon;Lapa, Tatyana;Castelo-Branco, Miguel;Voon, Valerie
强迫症（OCD）的强迫行为可能与决策异常有关。无法做出最终决定，例如，患者无法决定自己的手是否足够干净，可能反映了在做出决定之前未能积累足够的证据。在这里，我们调查的过程中，强迫症的证据积累的知觉歧视，假设增强证据积累相对于健康志愿者。28例强迫症患者和35名正常对照者被试分别采用低水平视知觉任务（随机点运动任务，RDMT）和两种反应冲突控制任务进行测试。使用不同运动连贯性水平的回归分析和分层漂移扩散模型（HDDM）来表征RDMT中各组之间的反应策略。患者在高不确定性的感知环境下需要更多的证据，如更长的反应时间和更高的决策边界。HDDM定义了当累积的噪声证据达到决策边界时的决策，进一步显示了向决策边界的较慢漂移率，反映了在低不确定性下进入患者决策过程的证据质量较差。随着金钱激励强调速度，患者降低了相对于对照组的决策阈值，在低不确定性中积累了较少的证据。这些发现与视知觉缺陷和反应冲突无关。这项研究提供了证据，受损的决策形成过程中强迫症，高和低的不确定性背景下的证据积累（决策阈值）和收集的证据的质量（漂移率）的差异影响。它进一步强调，强迫症患者是敏感的金钱激励提高速度的速度准确性权衡，提高证据积累。
The compulsive behaviour underlying Obsessive-Compulsive Disorder (OCD) may be related to abnormalities in decision-making. The inability to commit to ultimate decisions, e.g. patients unable to decide whether their hands are sufficiently clean, may reflect failures in accumulating sufficient evidence prior to a decision. Here we investigate the process of evidence accumulation in OCD in perceptual discrimination, hypothesizing enhanced evidence accumulation relative to healthy volunteers. Twenty-eight OCD patients and 35 controls were tested with a low-level visual perceptual task (random-dot-motion task, RDMT) and two response conflict control tasks. Regression analysis across different motion coherence levels and hierarchical drift diffusion modelling (HDDM) were used to characterize response strategies between groups in the RDMT. Patients required more evidence under high uncertainty perceptual contexts, as indexed by longer response time and higher decision boundaries. HDDM, which defines a decision when accumulated noisy evidence reaches a decision boundary, further showed slower drift rate towards the decision boundary reflecting poorer quality of evidence entering the decision process in patients under low uncertainty. With monetary incentives emphasizing speed, patients decreased the decision thresholds relative to controls, accumulating less evidence in low uncertainty. These findings were unrelated to visual perceptual deficits and response conflict. This study provides evidence for impaired decision-formation processes in OCD, with a differential influence of high and low uncertainty contexts on evidence accumulation (decision threshold) and on the quality of evidence gathered (drift rates). It further emphasizes that OCD patients are sensitive to monetary incentives heightening speed in the speed-accuracy tradeoff, improving evidence accumulation.
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影响因子：
3.7
作者：
Kiehl, KA;Liddle, PF;Hopfinger, JB
通讯作者：
Hopfinger, JB
影响因子：
8.2
作者：
Gehring, WJ;Himle, J;Nisenson, LG
通讯作者：
Nisenson, LG
影响因子：
1.7
作者：
Fine, Cordelia;Gardner, Mark;Gold, Ian
通讯作者：
Gold, Ian
影响因子：
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作者：
Huddy, V. C.;Clark, L.;Joyce, E. M.
通讯作者：
Joyce, E. M.
影响因子：
6.9
作者：
Fear, CF;Healy, D
通讯作者：
Healy, D