Effects of High Levels of Deoxynivalenol and Zearalenone on Growth Performance, and Hematological and Immunological Parameters in Pigs.
Effects of High Levels of Deoxynivalenol and Zearalenone on Growth Performance, and Hematological and Immunological Parameters in Pigs.
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高水平脱氧雪腐镰刀菌烯醇和玉米赤霉烯酮对猪生长性能以及血液学和免疫学参数的影响。
DOI：
10.3390/toxins10030114
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发表时间：
2018-03-07
期刊：
影响因子：
4.2
通讯作者：
Lee SD
中科院分区：
文献类型：
--
作者：
Reddy KE;Song J;Lee HJ;Kim M;Kim DW;Jung HJ;Kim B;Lee Y;Yu D;Kim DW;Oh YK;Lee SD
背景：脱氧雪腐镰刀菌醇（DON）和玉米赤霉烯酮（ZEN）是镰刀菌产生的常见食品污染物。真菌毒素对人类和养殖动物都有潜在的毒理学影响，对健康有潜在的危害。方法：对3组猪进行分析：对照组（饲喂标准饲粮），DON组和ZEN组（分别饲喂含8 mg/kg DON和0.8 mg/kg ZEN的饲粮），为期4周。结果：DON和ZEN暴露降低了体重（BW）、平均日采食量（ADFI）、食物转化率（FCR）和血清免疫球蛋白（Ig）G和IgM水平。两组小鼠血清中总抗氧化水平显著降低，尿液中总抗氧化水平显著升高。此外，DON和ZEN暴露会增加尿液中的血清素水平。血液学参数不受毒素的影响。两组肾脏切片显微镜下病变都很明显：我们发现DON组有散发性间质性肾炎，ZEN组肾小球萎缩。DON-和zen暴露的猪组织中炎症因子和趋化因子标记基因的表达水平降低。结论：长期摄入高剂量DON和ZEN会改变猪的免疫反应，造成器官损伤，并可能与猪的多种疾病有关。
Background: Deoxynivalenol (DON) and zearalenone (ZEN) are common food contaminants produced by Fusarium sp. Mycotoxins are a potential health hazard because of their toxicological effects on both humans and farmed animals. Methods: We analyzed three groups of pigs: a control group (fed a standard diet), and the DON and ZEN groups, fed a diet containing 8 mg/kg DON and 0.8 mg/kg ZEN respectively, for four weeks. Results: DON and ZEN exposure decreased body weight (BW), average daily feed intake (ADFI), food conversion rate (FCR), and the serum levels of immunoglobulin (Ig)G and IgM. The total antioxidant levels significantly decreased in serum and increased in urine samples of both treatment groups. Additionally, DON and ZEN exposure increased serotonin levels in urine. Hematological parameters were not affected by the investigated toxins. Microscopic lesions were evident in sections of kidneys from either treatment group: we found sporadic interstitial nephritis in the DON group and renal glomerulus atrophy in the ZEN group. The expression levels of inflammatory cytokines and chemokine marker genes were reduced in tissues from DON- and ZEN-exposed pigs. Conclusions: chronic ingestion of high doses of DON and ZEN alters the immune response and causes organs damage, and might be associated with various diseases in pigs.
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影响因子：
3.2
作者：
Kim, Dong-Ho;Hong, Sung-Yong;Chung, Soo Hyun
通讯作者：
Chung, Soo Hyun
影响因子：
2.2
作者：
BERGSJO, B;LANGSETH, W;LARSEN, HJS
通讯作者：
LARSEN, HJS
DOI：
10.1080/0003942031000161045
发表时间：
2004-02-01
期刊：
ARCHIVES OF ANIMAL NUTRITION-ARCHIV FUR TIERERNAHRUNG
影响因子：
--
作者：
Dänicke, S;Valenta, H;Flachowsky, G
通讯作者：
Flachowsky, G
影响因子：
--
作者：
Lewczuk, Bogdan;Przybylska-Gornowicz, Barbara;Gajecki, Maciej
通讯作者：
Gajecki, Maciej
影响因子：
4.2
作者：
Alizadeh A;Braber S;Akbari P;Garssen J;Fink-Gremmels J
通讯作者：
Fink-Gremmels J