Early-life bisphenol a exposure and child body mass index: a prospective cohort study.
Early-life bisphenol a exposure and child body mass index: a prospective cohort study.
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DOI：
10.1289/ehp.1408258
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发表时间：
2014-11
影响因子：
10.4
通讯作者：
Venners SA
中科院分区：
文献类型：
--
作者：
Braun JM;Lanphear BP;Calafat AM;Deria S;Khoury J;Howe CJ;Venners SA
背景资料：早期接触双酚A（BPA）可能会增加儿童肥胖的风险，但很少有前瞻性流行病学研究调查这种关系。目的：我们试图确定来自俄亥俄州辛辛那提的297对母子中，早期生活中暴露于BPA是否与2 - 5岁时体重指数（BMI）增加相关（HOME研究）。研究方法：在第二和第三个三个月的孕妇和他们的孩子在1岁和2岁收集的样本中测量尿BPA浓度。BMI z评分根据2 - 5岁期间每年进行的体重/身高测量值计算。我们使用线性混合模型来估计BMI差异或随着肌酐标准化BPA浓度增加的轨迹。结果如下：校正混杂因素后，产前（β =-0.1; 95% CI：-0.5，0.3）或儿童早期（β =-0.2; 95% CI：-0.6，0.1）BPA浓度每增加10倍，儿童BMI就会适度降低，但无显著性。这些反向关联在女孩中明显强于男孩[产前效应测量修正（EMM）p值= 0.30，儿童早期EMM p值= 0.05]，但性别特异性关联不精确。BPA水平最高的儿童在2岁时的BMI较低（差异=-0.3; 95% CI：-0.6，0.0），2 - 5年BMI斜率增加较大（BMI每年增加= 0.12; 95%CI：0.07，0.18）比最低三分位数的儿童（BMI每年增加= 0.07; 95%CI：0.01，0.13）。所有相关性均减弱，肌酐未恢复正常。结论：产前和儿童早期BPA暴露与2 - 5岁时BMI增加无关，但较高的儿童早期BPA暴露与此期间的加速生长有关。引文：Braun JM，Lanphear BP，卡拉法特AM，Deria S，Khoury J，Howe CJ，Venners SA。2014.早期双酚A暴露与儿童体重指数：一项前瞻性队列研究环境健康展望122：1239 - 1245; http：//www.example.com
Background: Early-life exposure to bisphenol A (BPA) may increase childhood obesity risk, but few prospective epidemiological studies have investigated this relationship. Objective: We sought to determine whether early-life exposure to BPA was associated with increased body mass index (BMI) at 2–5 years of age in 297 mother–child pairs from Cincinnati, Ohio (HOME Study). Methods: Urinary BPA concentrations were measured in samples collected from pregnant women during the second and third trimesters and their children at 1 and 2 years of age. BMI z-scores were calculated from weight/height measures conducted annually from 2 through 5 years of age. We used linear mixed models to estimate BMI differences or trajectories with increasing creatinine-normalized BPA concentrations. Results: After confounder adjustment, each 10-fold increase in prenatal (β = –0.1; 95% CI: –0.5, 0.3) or early-childhood (β = –0.2; 95% CI: –0.6, 0.1) BPA concentrations was associated with a modest and nonsignificant reduction in child BMI. These inverse associations were suggestively stronger in girls than in boys [prenatal effect measure modification (EMM) p-value = 0.30, early-childhood EMM p-value = 0.05], but sex-specific associations were imprecise. Children in the highest early-childhood BPA tercile had lower BMI at 2 years (difference = –0.3; 95% CI: –0.6, 0.0) and larger increases in their BMI slope from 2 through 5 years (BMI increase per year = 0.12; 95% CI: 0.07, 0.18) than children in the lowest tercile (BMI increase per year = 0.07; 95% CI: 0.01, 0.13). All associations were attenuated without creatinine normalization. Conclusions: Prenatal and early-childhood BPA exposures were not associated with increased BMI at 2–5 years of age, but higher early-childhood BPA exposures were associated with accelerated growth during this period. Citation: Braun JM, Lanphear BP, Calafat AM, Deria S, Khoury J, Howe CJ, Venners SA. 2014. Early-life bisphenol A exposure and child body mass index: a prospective cohort study. Environ Health Perspect 122:1239–1245; http://dx.doi.org/10.1289/ehp.1408258
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影响因子：
10.4
作者：
Braun JM;Yolton K;Dietrich KN;Hornung R;Ye X;Calafat AM;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
1.5
作者：
Ross MG;Desai M
通讯作者：
Desai M
影响因子：
10.4
作者：
Rauch SA;Braun JM;Barr DB;Calafat AM;Khoury J;Montesano AM;Yolton K;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
4.9
作者：
Freedman, DS;Wang, J;Horlick, M
通讯作者：
Horlick, M
Chamacos队列中儿童期的产前和产后双酚A暴露和体重指数。
影响因子：
10.4
作者：
Harley KG;Aguilar Schall R;Chevrier J;Tyler K;Aguirre H;Bradman A;Holland NT;Lustig RH;Calafat AM;Eskenazi B
通讯作者：
Eskenazi B