Mapping the organization of axis of motion selective features in human area MT using high-field fMRI.
Mapping the organization of axis of motion selective features in human area MT using high-field fMRI.
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DOI：
10.1371/journal.pone.0028716
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Yacoub E
中科院分区：
文献类型：
--
作者：
Zimmermann J;Goebel R;De Martino F;van de Moortele PF;Feinberg D;Adriany G;Chaimow D;Shmuel A;Uğurbil K;Yacoub E
高磁场下的功能性磁共振成像（fMRI）使得以高精度和灵敏度研究活体人脑的柱状组织成为可能。到目前为止，这些结果仅限于早期视觉皮层（V1）的组织原则。虽然中颞区（MT）已被确定为第一个外纹视觉区显示出柱状组织在猴子，MT的柱状响应特性和地形布局在人类的证据仍然难以捉摸。使用各种方法的研究表明，在猴子类似的响应特性，但未能提供直接的证据，在人类MT区的运动选择性的方向或轴。通过结合最先进的脉冲序列设计，在所有三个维度（0.8毫米各向同性），优化的线圈设计，磁场磁铁（7特斯拉）和新的高分辨率皮层网格采样分析工具的高空间分辨率，我们提供了第一个直接的证据，大规模的运动轴选择性功能组织在人类区域MT密切匹配的预测从地形柱级模拟。
Functional magnetic resonance imaging (fMRI) at high magnetic fields has made it possible to investigate the columnar organization of the human brain in vivo with high degrees of accuracy and sensitivity. Until now, these results have been limited to the organization principles of early visual cortex (V1). While the middle temporal area (MT) has been the first identified extra-striate visual area shown to exhibit a columnar organization in monkeys, evidence of MT's columnar response properties and topographic layout in humans has remained elusive. Research using various approaches suggests similar response properties as in monkeys but failed to provide direct evidence for direction or axis of motion selectivity in human area MT. By combining state of the art pulse sequence design, high spatial resolution in all three dimensions (0.8 mm isotropic), optimized coil design, ultrahigh field magnets (7 Tesla) and novel high resolution cortical grid sampling analysis tools, we provide the first direct evidence for large-scale axis of motion selective feature organization in human area MT closely matching predictions from topographic columnar-level simulations.
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影响因子：
9.2
作者：
Kamitani, Yukiyasu;Tong, Frank
通讯作者：
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影响因子：
3.4
作者：
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影响因子：
2.5
作者：
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DOI：
10.1073/pnas.0610821104
发表时间：
2007-07-10
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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