Progress and challenges toward the development of vaccines against avian infectious bronchitis.
Progress and challenges toward the development of vaccines against avian infectious bronchitis.
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DOI：
10.1155/2015/424860
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发表时间：
2015
影响因子：
4.1
通讯作者：
Omar AR
中科院分区：
文献类型：
--
作者：
Bande F;Arshad SS;Bejo MH;Moeini H;Omar AR
鸡传染性支气管炎是一种分布广泛的禽类疾病，对养禽业有着巨大的经济影响。新的IBV基因型的不断出现和不同IBV基因型之间缺乏交叉保护已经成为一个重要的挑战。尽管IB减毒活疫苗显著诱导有效的免疫应答，但其潜在的毒力返强、母源抗体中和以及重组和突变事件的风险是其使用的重要关注点。另一方面，灭活疫苗诱导较弱的免疫应答，可能需要多次给药和/或使用佐剂，这可能具有潜在的安全风险和增加的经济负担。因此，广泛寻求替代IB疫苗。重组DNA技术的最新进展已经产生了实验性IB疫苗，其在抗体和T细胞应答方面显示出与减毒活疫苗相当的前景。重组DNA疫苗也已被增强以靶向多种血清型，并且它们的功效已使用递送载体、纳米佐剂和卵内疫苗接种方法得到改善。虽然大多数重组IBDNA疫苗尚未获得许可，但预计这些类型的疫苗可能会成为未来诱导针对多种IBV血清型的交叉保护的疫苗。
Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes.
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