The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep.
The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep.
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DOI：
10.1038/s41467-021-25378-w
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发表时间：
2021-08-25
影响因子：
16.6
通讯作者：
Hattar S
中科院分区：
文献类型：
--
作者：
Zhang Z;Beier C;Weil T;Hattar S
光通过一个神经回路调节日常睡眠节律，该神经回路将内在光敏视网膜神经节细胞（ipRGC）连接到昼夜节律起搏器（视交叉上核）。然而，光也会以一种与昼夜节律无关的方式严重影响睡眠。涉及光对睡眠的急性影响的神经回路仍然未知。在这里，我们发现了一个驱动这种急性光反应的神经回路，独立于视交叉上核，但仍然通过ipRGC。我们表明，ipRGCs基本上支配视前区（POA）介导急性光对小鼠睡眠的影响。一致地，POA投射ipRGC或光响应POA神经元的激活增加非快速眼动（NREM）睡眠而不影响REM睡眠。此外，抑制光反应的POA神经元阻断了NREM睡眠的急性光效应。接受ipRGC输入的主要光响应性POA神经元属于促肾上腺皮质激素释放激素亚群。值得注意的是，光反应的POA神经元是抑制性的，并投射到众所周知的促进觉醒的大脑区域，如结节乳头核和下丘脑外侧。因此，ipRGC-POA回路的激活抑制了唤醒脑区域以驱动光诱导的NREM睡眠。我们的研究结果揭示了一个功能性的视网膜-大脑回路，它对于光线对睡眠的急性影响是必要的，也是足够的。视前区（POA）对睡眠调节至关重要，但其在急性非昼夜节律光对睡眠的影响中的作用尚不清楚。作者表明，内在光敏视网膜神经节细胞提供了大量的输入到POA，并通过这些调节非快速眼动（NREM）睡眠的量。
Light regulates daily sleep rhythms by a neural circuit that connects intrinsically photosensitive retinal ganglion cells (ipRGCs) to the circadian pacemaker, the suprachiasmatic nucleus. Light, however, also acutely affects sleep in a circadian-independent manner. The neural circuits involving the acute effect of light on sleep remain unknown. Here we uncovered a neural circuit that drives this acute light response, independent of the suprachiasmatic nucleus, but still through ipRGCs. We show that ipRGCs substantially innervate the preoptic area (POA) to mediate the acute light effect on sleep in mice. Consistently, activation of either the POA projecting ipRGCs or the light-responsive POA neurons increased non-rapid eye movement (NREM) sleep without influencing REM sleep. In addition, inhibition of the light-responsive POA neurons blocked the acute light effects on NREM sleep. The predominant light-responsive POA neurons that receive ipRGC input belong to the corticotropin-releasing hormone subpopulation. Remarkably, the light-responsive POA neurons are inhibitory and project to well-known wakefulness-promoting brain regions, such as the tuberomammillary nucleus and the lateral hypothalamus. Therefore, activation of the ipRGC-POA circuit inhibits arousal brain regions to drive light-induced NREM sleep. Our findings reveal a functional retina-brain circuit that is both necessary and sufficient for the acute effect of light on sleep. The preoptic area (POA) is critical for sleep regulation but its role in acute, non-circadian, light effects on sleep are unclear. The authors show that intrinsically photosensitive retinal ganglion cells provide substantial input into the POA and through these modulate the amount of non-rapid eye movement (NREM) sleep.
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DOI：
10.1073/pnas.0808312105
发表时间：
2008-12-16
影响因子：
11.1
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Altimus, C. M.;Guler, A. D.;Hattar, S.
通讯作者：
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