The Relationship of Fat Distribution and Insulin Resistance with Lumbar Spine Bone Mass in Women.
The Relationship of Fat Distribution and Insulin Resistance with Lumbar Spine Bone Mass in Women.
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DOI：
10.1371/journal.pone.0129764
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Nogueira-Barbosa MH
中科院分区：
文献类型：
--
作者：
de Paula FJ;de Araújo IM;Carvalho AL;Elias J Jr;Salmon CE;Nogueira-Barbosa MH
骨髓含有大量的身体脂肪组织（BMAT）。虽然BMAT可能是骨建模和重建的能量来源，但其增加也可能代表成骨细胞分化的损伤。BMAT、骨量和胰岛素敏感性之间的关系仅部分了解，似乎取决于具体情况。本研究旨在评估BMAT与腰椎骨密度、内脏脂肪组织、肝内脂质、HOMA-IR以及血清胰岛素和葡萄糖水平的相关性。这项横断面临床研究包括31名非糖尿病妇女，但11名有糖尿病前期状态。双能X线吸收法用于测量骨密度，磁共振成像用于评估BMAT、内脏脂肪组织和肝脏中的脂肪沉积。我们的研究结果表明，在非糖尿病患者中，腰椎骨密度与BMAT呈负相关，在调整体重、年龄、BMI和身高后，这种趋势仍然存在。虽然内脏脂肪组织和肝内脂质与血清胰岛素水平呈正相关，但BMAT与血清胰岛素水平之间无相关性。相反，BMAT和血清葡萄糖水平之间存在正相关关系，而其他脂肪沉积则没有观察到这种相关性。在调整体重、BMI、身高和年龄后，这些关系不适用。本研究表明，在一组以非肥胖女性为主的人群中，胰岛素抵抗与BMAT之间的关联并不是早期事件，而内脏脂肪组织和肝内脂质则是如此。另一方面，BMAT与骨密度呈负相关。总之，结果支持骨与能量代谢具有复杂和非线性关系的观点。
Bone marrow harbors a significant amount of body adipose tissue (BMAT). While BMAT might be a source of energy for bone modeling and remodeling, its increment can also represent impairment of osteoblast differentiation. The relationship between BMAT, bone mass and insulin sensitivity is only partially understood and seems to depend on the circumstances. The present study was designed to assess the association of BMAT with bone mineral density in the lumbar spine as well as with visceral adipose tissue, intrahepatic lipids, HOMA-IR, and serum levels of insulin and glucose. This cross-sectional clinical investigation included 31 non-diabetic women, but 11 had a pre-diabetes status. Dual X-ray energy absorptiometry was used to measure bone mineral density and magnetic resonance imaging was used to assess fat deposition in BMAT, visceral adipose tissue and liver. Our results suggest that in non-diabetic, there is an inverse relationship between bone mineral density in lumbar spine and BMAT and a trend persists after adjustment for weight, age, BMI and height. While there is a positive association between visceral adipose tissue and intrahepatic lipids with serum insulin levels, there is no association between BMAT and serum levels of insulin. Conversely, a positive relationship was observed between BMAT and serum glucose levels, whereas this association was not observed with other fat deposits. These relationships did not apply after adjustment for body weight, BMI, height and age. The present study shows that in a group of predominantly non-obese women the association between insulin resistance and BMAT is not an early event, as occurs with visceral adipose tissue and intrahepatic lipids. On the other hand, BMAT has a negative relationship with bone mineral density. Taken together, the results support the view that bone has a complex and non-linear relationship with energy metabolism.
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DOI：
10.1359/jbmr.080713
发表时间：
2008-12
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Moyer-Mileur LJ;Slater H;Jordan KC;Murray MA
通讯作者：
Murray MA
影响因子：
2.9
作者：
Fishbein, M;Castro, F;Stevens, WR
通讯作者：
Stevens, WR
影响因子：
5.8
作者：
Russell, Melissa;Mendes, Nara;Misra, Madhusmita
通讯作者：
Misra, Madhusmita
影响因子：
1.8
作者：
Kitajima, Masaru;Shigematsu, Masamori;Hotokebuchi, Takao
通讯作者：
Hotokebuchi, Takao
脂肪组织刺激青春期前儿童的骨骼生长。
DOI：
10.1210/jc.2006-0332
发表时间：
2006-07
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Clark EM;Ness AR;Tobias JH
通讯作者：
Tobias JH