Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis.
Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis.
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脂肪酸代谢物作为非颤抖产热的新型调节剂
DOI：
10.1007/164_2018_150
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发表时间：
2018
影响因子：
--
通讯作者：
Klingenspor M.
中科院分区：
文献类型：
--
作者：
Maurer SF;Dieckmann S;Kleigrewe K;Colson C;Amri EZ;Klingenspor M.
脂肪酸作为解偶联蛋白1的激活剂和线粒体产热的燃料，是脂肪细胞非颤抖性产热的重要贡献者。新的证据表明，这种产热机制的贡献，其转化为生物活性化合物。哺乳动物细胞产生过多的氧脂素和内源性大麻素，其中一些已被确定为影响棕色和棕色脂肪细胞的丰度或产热活性。这些效应物在局部或远处产生，并通过与这些细胞直接相互作用或间接通过次级机制向产热脂肪细胞发出信号。这些相互作用是由受体介导的通路的激活引起的。这些化合物的内源性产生倾向于通过饮食摄入相应的前体脂肪酸来调节。因此，营养干预对解偶联蛋白1衍生的产热的影响可能至少部分地由支持性氧脂素和内源性大麻素谱的产生所赋予。在未来的研究中，这一系统的操作将有助于阐明这些化合物作为非颤抖产热的新型内源性调节剂的生理潜力。
Fatty acids are essential contributors to adipocyte-based non-shivering thermogenesis by acting as activators of uncoupling protein 1 and serving as fuel for mitochondrial heat production. Novel evidence suggests a contribution to this thermogenic mechanism by their conversion to bioactive compounds. Mammalian cells produce a plethora of oxylipins and endocannabinoids, some of which have been identified to affect the abundance or thermogenic activity of brown and brite adipocytes. These effectors are produced locally or at distant sites and signal toward thermogenic adipocytes via a direct interaction with these cells or indirectly via secondary mechanisms. These interactions are evoked by the activation of receptor-mediated pathways. The endogenous production of these compounds is prone to modulation by the dietary intake of the respective precursor fatty acids. The effect of nutritional interventions on uncoupling protein 1-derived thermogenesis may thus at least in part be conferred by the production of a supportive oxylipin and endocannabinoid profile. The manipulation of this system in future studies will help to elucidate the physiological potential of these compounds as novel, endogenous regulators of non-shivering thermogenesis.
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影响因子：
64.8
作者：
Nguyen, Khoa D.;Qiu, Yifu;Cui, Xiaojin;Goh, Y. P. Sharon;Mwangi, Julia;David, Tovo;Mukundan, Lata;Brombacher, Frank;Locksley, Richard M.;Chawla, Ajay
通讯作者：
Chawla, Ajay
DOI：
10.1016/j.bbalip.2014.10.002
发表时间：
2015-04
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Kuhn H;Banthiya S;van Leyen K
通讯作者：
van Leyen K
影响因子：
82.9
作者：
Fischer K;Ruiz HH;Jhun K;Finan B;Oberlin DJ;van der Heide V;Kalinovich AV;Petrovic N;Wolf Y;Clemmensen C;Shin AC;Divanovic S;Brombacher F;Glasmacher E;Keipert S;Jastroch M;Nagler J;Schramm KW;Medrikova D;Collden G;Woods SC;Herzig S;Homann D;Jung S;Nedergaard J;Cannon B;Tschöp MH;Müller TD;Buettner C
通讯作者：
Buettner C
影响因子：
3.6
作者：
Balvers, Michiel G. J.;Verhoeckx, Kitty C. M.;Bijlsma, Sabina;Rubingh, Carina M.;Meijerink, Jocelijn;Wortelboer, Heleen M.;Witkamp, Renger F.
通讯作者：
Witkamp, Renger F.
影响因子：
7.7
作者：
Carmona, Maria Carmen;Louche, Katie;Penicaud, Luc
通讯作者：
Penicaud, Luc