Pachychoroid: current concepts on clinical features and pathogenesis.
Pachychoroid: current concepts on clinical features and pathogenesis.
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DOI：
10.1007/s00417-020-04940-0
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Okada AA
中科院分区：
文献类型：
--
作者：
Castro-Navarro V;Behar-Cohen F;Chang W;Joussen AM;Lai TYY;Navarro R;Pearce I;Yanagi Y;Okada AA
“厚脉络膜”一词是指一种新描述的表型，其中功能和结构的脉络膜变化被认为在相关视网膜疾病的频谱中起关键的致病作用。更详细地了解脉络膜是如何参与这一频谱的，更好地了解厚脉络膜表型最相关的临床症状，对于区分这些疾病与其他视网膜疾病非常重要。我们的目的是提供厚脉络膜的文献综述和可能存在于包括在频谱的病理共性，并提供详细的检查，监测和管理这些疾病。我们在PubMed网络平台上检索相关研究，使用以下关键词：厚脉络膜、厚脉络膜色素上皮病、厚脉络膜新生血管病、动脉瘤样1型新生血管、局点脉络膜挖掘、乳头周围厚脉络膜综合征、厚脉络膜血管病、厚脉络膜地理萎缩、厚脓性。我们选择了157篇出版物，并确定了与厚脉络膜相关的最重要特征。厚脉络膜最显著的特征是在后极的绒毛膜毛细血管减少或缺失的情况下，在脉络膜内存在肥厚或充血的血管，而不是本身增厚的脉络膜。然而，需要其他定性/定量特征来区分无并发症的厚脉络膜与病理性厚脉络膜临床谱，这可能与渗出、新生血管和/或视网膜色素上皮和光受体萎缩有关。厚脉络膜最显著的特征似乎是在绒毛毛细血管减少或缺失的区域下存在大血管。了解厚脉络膜频谱中不同疾病的特征和发病机制可能有助于患者的管理。
The term “pachychoroid” refers to a newly described phenotype in which functional and structural choroidal changes are thought to play a key pathogenic role in a spectrum of related retinal disorders. A more detailed understanding of how the choroid is involved within this spectrum and a better knowledge of the most relevant clinical signs of the pachychoroid phenotype are important to differentiate these disorders from other retinal conditions. Our objectives are to provide a literature review of pachychoroid and the commonalities that may be present across pathologies included in the spectrum, and to provide details on the examination, monitoring, and management of these disorders. We searched the PubMed web platform to identify relevant studies using the following keywords: pachychoroid, pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, aneurysmal type 1 neovascularization, focal choroidal excavation, peripapillary pachychoroid syndrome, vasculopathy pachysclera, pachychoroid geographic atrophy, and pachydrusen. We selected 157 publications and identified the most important features related to pachychoroid. The presence of hypertrophic or congested vessels in the choroid, not thickened choroid per se, under an area of reduced or absent choriocapillaris in the posterior pole seems to be the most salient feature of pachychoroid. However, other qualitative/quantitative features are needed to differentiate the uncomplicated pachychoroid from the pathological pachychoroid clinical spectrum, which may be associated with exudation, neovascularization, and/or retinal pigment epithelium and photoreceptor atrophy. The most salient feature of pachychoroid appears to be the presence of large vessels under an area of reduced or absent choriocapillaris. Knowledge of the features and pathogenesis of the different disorders in the pachychoroid spectrum may assist in the management of patients.
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影响因子：
4.2
作者：
Koizumi, Hideki;Yamagishi, Tetsuya;Kinoshita, Shigeru
通讯作者：
Kinoshita, Shigeru
中心性浆液性脉络膜视网膜病变的光学相干断层血管造影
DOI：
10.1097/iae.0000000000001064
发表时间：
2016-11-01
影响因子：
3.3
作者：
Chan, Szy Yann;Wang, Qian;Jonas, Jost B.
通讯作者：
Jonas, Jost B.
DOI：
10.1097/00006982-199911000-00005
发表时间：
1999-01-01
影响因子：
3.3
作者：
Iida, T;Kishi, S;Shimizu, K
通讯作者：
Shimizu, K
影响因子：
4.5
作者：
Hiroe, Takashi;Kishi, Shoji
通讯作者：
Kishi, Shoji
DOI：
10.1097/iae.0b013e31824f91e8
发表时间：
2012-09-01
影响因子：
3.3
作者：
Koh, Adrian;Lee, Won Ki;Lim, Tock H.
通讯作者：
Lim, Tock H.