Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States.
Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States.
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DOI：
10.1038/s41467-023-39782-x
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发表时间：
2023-07-10
影响因子：
16.6
通讯作者：
Wan, Xiu-Feng
中科院分区：
文献类型：
--
作者：
Feng, Aijing;Bevins, Sarah;Chandler, Jeff;DeLiberto, Thomas J.;Ghai, Ria;Lantz, Kristina;Lenoch, Julianna;Retchless, Adam;Shriner, Susan;Tang, Cynthia Y.;Tong, Suxiang Sue;Torchetti, Mia;Uehara, Anna;Wan, Xiu-Feng
SARS-CoV-2是一种人畜共患病病毒，已有文献证明人与动物之间存在双向传播。SARS-CoV-2从人到自由放养的白尾鹿(Odocoileus Virginianus)的传播构成了独特的公共卫生风险，因为可能会建立宿主，在那里变异可能持续和进化。2021年11月至2022年4月，我们在华盛顿特区和美国26个州收集了8830只自由放养的白尾鹿的呼吸道样本。我们获得了391个序列，鉴定了34个Pango血统，包括Alpha、Gamma、Delta和Omicron变体。进化分析表明，这些白尾鹿病毒起源于至少109个来自人类的独立溢出，这导致了39例当地鹿对鹿的传播，以及3例从白尾鹿返回人类的潜在溢出。病毒反复适应白尾鹿，在SPEKE和其他蛋白质上反复发生氨基酸替换。总体而言，我们的发现表明，多个SARS-CoV-2谱系被引入，成为地方性疾病，并在白尾鹿中共同传播。SARS-CoV-2病毒已被证明可在人与动物之间传播，为病毒库提供了机会。在这里，作者展示了美国各地自由放养的白尾鹿的SARS-CoV-2谱系，这是在人类种群的谱系下降很久之后。
SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed deer (Odocoileus virginianus) poses a unique public health risk due to the potential for reservoir establishment where variants may persist and evolve. We collected 8,830 respiratory samples from free-ranging white-tailed deer across Washington, D.C. and 26 states in the United States between November 2021 and April 2022. We obtained 391 sequences and identified 34 Pango lineages including the Alpha, Gamma, Delta, and Omicron variants. Evolutionary analyses showed these white-tailed deer viruses originated from at least 109 independent spillovers from humans, which resulted in 39 cases of subsequent local deer-to-deer transmission and three cases of potential spillover from white-tailed deer back to humans. Viruses repeatedly adapted to white-tailed deer with recurring amino acid substitutions across spike and other proteins. Overall, our findings suggest that multiple SARS-CoV-2 lineages were introduced, became enzootic, and co-circulated in white-tailed deer. The SARS-CoV-2 virus has been documented to transmit between humans and animals, providing opportunities for viral reservoirs. Here, the authors show SARS-CoV-2 lineages in free-ranging white-tailed deer across the United States, long after the lineages had declined in human populations.
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DOI：
10.1073/pnas.2215067120
发表时间：
2023-02-07
影响因子：
11.1
作者：
Caserta, Leonardo C.;Martins, Mathias;Butt, Salman L.;Hollingshead, Nicholas A.;Covaleda, Lina M.;Ahmed, Sohel;Everts, Mia R. R.;Schuler, Krysten L.;Diel, Diego G.
通讯作者：
Diel, Diego G.
Biopython：用于计算分子生物学和生物信息学的免费 Python 工具。
DOI：
10.1093/bioinformatics/btp163
发表时间：
2009-06-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Cock PJ;Antao T;Chang JT;Chapman BA;Cox CJ;Dalke A;Friedberg I;Hamelryck T;Kauff F;Wilczynski B;de Hoon MJ
通讯作者：
de Hoon MJ
DOI：
10.1073/pnas.2114828118
发表时间：
2021-11-23
影响因子：
11.1
作者：
Chandler JC;Bevins SN;Ellis JW;Linder TJ;Tell RM;Jenkins-Moore M;Root JJ;Lenoch JB;Robbe-Austerman S;DeLiberto TJ;Gidlewski T;Kim Torchetti M;Shriner SA
通讯作者：
Shriner SA
影响因子：
64.8
作者：
Hale VL;Dennis PM;McBride DS;Nolting JM;Madden C;Huey D;Ehrlich M;Grieser J;Winston J;Lombardi D;Gibson S;Saif L;Killian ML;Lantz K;Tell RM;Torchetti M;Robbe-Austerman S;Nelson MI;Faith SA;Bowman AS
通讯作者：
Bowman AS
影响因子：
5
作者：
Emam M;Oweda M;Antunes A;El-Hadidi M
通讯作者：
El-Hadidi M