SARS-CoV-2 infection in free-ranging white-tailed deer.
SARS-CoV-2 infection in free-ranging white-tailed deer.
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DOI：
10.1038/s41586-021-04353-x
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Bowman AS
中科院分区：
文献类型：
--
作者：
Hale VL;Dennis PM;McBride DS;Nolting JM;Madden C;Huey D;Ehrlich M;Grieser J;Winston J;Lombardi D;Gibson S;Saif L;Killian ML;Lantz K;Tell RM;Torchetti M;Robbe-Austerman S;Nelson MI;Faith SA;Bowman AS
人类已经用SARS-CoV-2病毒感染了广泛的动物，但尚未观察到新的天然动物宿主的建立。在这里，我们记录了自由放养的白尾鹿（Odocoileus virginianus）对SARS-CoV-2病毒的感染高度敏感，暴露于一系列来自人类的病毒多样性，并且能够在自然界中持续传播。2021年1月至3月期间，在俄亥俄州东北部（美国）从弗吉尼亚海鳗（Odocoileus virginianus）获得的鼻拭子中，通过rRT-PCR检测到超过三分之一（129/360，35.8%）的SARS-CoV-2病毒。6个地点的鹿感染了3个SARS-CoV-2谱系（B.1.2、B.1.582、B.1.596）。当时在俄亥俄州的人类中占主导地位的B.1.2病毒感染了四个地方的鹿。观察到B.1.2、B.1.582和B.1.596病毒可能在鹿与鹿之间传播，这使得病毒在刺突蛋白（包括受体结合结构域）和ORF 1中获得了在人类中不常见的氨基酸取代。没有观察到对人类的溢出，但这些发现表明SARS-CoV-2病毒具有在美国野生动物中传播的能力，可能为进化开辟新的途径。迫切需要建立全面的“一个健康”计划，以监测鹿，环境和全球其他野生动物宿主。
Humans have infected a wide range of animals with SARS-CoV-2 viruses, but the establishment of a new natural animal reservoir has not been observed. Here, we document that free-ranging white-tailed deer (Odocoileus virginianus) are highly susceptible to infection with SARS-CoV-2 virus, are exposed to a range of viral diversity from humans, and are capable of sustaining transmission in nature. SARS-CoV-2 virus was detected by rRT-PCR in more than one-third (129/360, 35.8%) of nasal swabs obtained from Odocoileus virginianus in northeast Ohio (USA) during January-March 2021. Deer in 6 locations were infected with 3 SARS-CoV-2 lineages (B.1.2, B.1.582, B.1.596). The B.1.2 viruses, dominant in humans in Ohio at the time, infected deer in four locations. Probable deer-to-deer transmission of B.1.2, B.1.582, and B.1.596 viruses was observed, allowing the virus to acquire amino acid substitutions in the spike protein (including the receptor-binding domain) and ORF1 that are infrequently seen in humans. No spillback to humans was observed, but these findings demonstrate that SARS-CoV-2 viruses have the capacity to transmit in US wildlife, potentially opening new pathways for evolution. There is an urgent need to establish comprehensive “One Health” programs to monitor deer, the environment, and other wildlife hosts globally.
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SARS-COV-2在人类和貂皮之间的貂皮农场上传播，然后回到人类。
DOI：
10.1126/science.abe5901
发表时间：
2021-01-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Oude Munnink BB;Sikkema RS;Nieuwenhuijse DF;Molenaar RJ;Munger E;Molenkamp R;van der Spek A;Tolsma P;Rietveld A;Brouwer M;Bouwmeester-Vincken N;Harders F;Hakze-van der Honing R;Wegdam-Blans MCA;Bouwstra RJ;GeurtsvanKessel C;van der Eijk AA;Velkers FC;Smit LAM;Stegeman A;van der Poel WHM;Koopmans MPG
通讯作者：
Koopmans MPG
影响因子：
39.3
作者：
Lu, Shuaiyao;Zhao, Yuan;Peng, Xiaozhong
通讯作者：
Peng, Xiaozhong
DOI：
10.3390/ani11051422
发表时间：
2021-05-16
期刊：
Animals : an open access journal from MDPI
影响因子：
--
作者：
Aguiló-Gisbert J;Padilla-Blanco M;Lizana V;Maiques E;Muñoz-Baquero M;Chillida-Martínez E;Cardells J;Rubio-Guerri C
通讯作者：
Rubio-Guerri C
DOI：
10.1073/pnas.2114828118
发表时间：
2021-11-23
影响因子：
11.1
作者：
Chandler JC;Bevins SN;Ellis JW;Linder TJ;Tell RM;Jenkins-Moore M;Root JJ;Lenoch JB;Robbe-Austerman S;DeLiberto TJ;Gidlewski T;Kim Torchetti M;Shriner SA
通讯作者：
Shriner SA
影响因子：
11.8
作者：
Freuling CM;Breithaupt A;Müller T;Sehl J;Balkema-Buschmann A;Rissmann M;Klein A;Wylezich C;Höper D;Wernike K;Aebischer A;Hoffmann D;Friedrichs V;Dorhoi A;Groschup MH;Beer M;Mettenleiter TC
通讯作者：
Mettenleiter TC