Angle-resolved low-coherence interferometry: an optical biopsy technique for clinical detection of dysplasia in Barrett's esophagus.

Angle-resolved low-coherence interferometry: an optical biopsy technique for clinical detection of dysplasia in Barrett's esophagus.
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DOI:
10.1586/egh.11.83
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发表时间:
2012-02
影响因子:
3.9
通讯作者:
Wax A
Wax A
中科院分区:
医学3区
文献类型:
--
作者:
Zhu Y;Terry NG;Wax A

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角度分辨低相干干涉测量法(a/LCI)是一种光学活检技术,可测量组织的散射光,以亚微米级精度确定细胞核大小。a/LCI探头可通过标准内窥镜的附件通道展开,并向医生提供反馈以指导物理活检。该技术已在动物和离体人体研究中得到验证,并已用于体内检测巴雷特食管患者的发育不良。在最近对46例Barrett食管患者的临床研究中,a/LCI能够以100%的灵敏度和84%的特异性检测异型增生。本报告回顾了该技术,并讨论了其潜在的临床实用性。
Angle-resolved low-coherence interferometry (a/LCI) is an optical biopsy technique that measures scattered light from tissue to determine nuclear size with submicron-level accuracy. The a/LCI probe can be deployed through the accessory channel of a standard endoscope and provides feedback to physicians to guide physical biopsies. The technique has been validated in animal and ex vivo human studies, and has been used to detect dysplasia in Barrett’s esophagus patients in vivo. In a recent clinical study of 46 Barrett’s esophagus patients, a/LCI was able to detect dysplasia with 100% sensitivity and 84% specificity. This report reviews the technique and discusses its potential clinical utility.
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