Triclosan exposure, transformation, and human health effects.

Triclosan exposure, transformation, and human health effects.
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三氯生暴露、转化和人类健康影响。

DOI:
10.1080/10937404.2017.1399306
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发表时间:
2017
期刊:
Journal of toxicology and environmental health. Part B, Critical reviews
影响因子:
--
通讯作者:
Gosse JA
Gosse JA
中科院分区:
其他
文献类型:
--
作者:
Weatherly LM;Gosse JA

文献摘要

参考文献

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三氯生 (TCS) 是一种应用广泛的抗菌剂,75% 的美国人可能通过消费品和个人护理产品接触到这种化合物。 2016年9月,美国食品和药物管理局(FDA)进行风险评估后,TCS被禁止在肥皂产品中使用。然而,牙膏、漱口水、洗手液和手术肥皂等其他个人护理产品中仍然存在高浓度的 TCS。三氯生很容易被人体皮肤和口腔粘膜吸收,并存在于各种人体组织和体液中。本次综述的目的是描述 TCS 暴露途径和水平以及代谢和转化过程。还总结了与 TCS 暴露相关的人类健康影响(例如生殖问题)的新兴文献。
Triclosan (TCS) is an antimicrobial used so ubiquitously that 75% of the U.S.A. population is likely exposed to this compound via consumer goods and personal care products. In September 2016, TCS was banned from soap products following the risk assessment by the U.S.A. Food and Drug Administration (FDA). However, TCS still remains, at high concentrations, in other personal care products such as toothpaste, mouthwash, hand sanitizer, and surgical soaps. Triclosan is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids. The aim of this review was to describe TCS exposure routes and levels as well as metabolism and transformation processes. The burgeoning literature on human health effects associated with TCS exposure, such as reproductive problems was also summarized.
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