Interspecies transmission and host restriction of avian H5N1 influenza virus.

Interspecies transmission and host restriction of avian H5N1 influenza virus.
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种间传播和宿主对鸟类H5N1流感病毒的限制。

DOI:
10.1007/s11427-009-0062-z
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发表时间:
2009-05
期刊:
Science in China. Series C, Life sciences
影响因子:
--
通讯作者:
Gao GF
Gao GF
中科院分区:
其他
文献类型:
--
作者:
Liu D;Liu X;Yan J;Liu WJ;Gao GF

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H5N1禽流感病毒在家禽中的长期流行和若干国家持续的散发人间感染引起了人们对另一场潜在大流行性流感的关注。由于怀疑以前的大流行源自禽类,因此对种间传播机制进行了密切调查。进入和融合是H5N1流感病毒进入影响宿主范围的宿主细胞的第一步。因此,受体使用的研究一直是近年来研究的重点。我们现在知道唾液酸的结构和分布在不同的物种,甚至在同一宿主的不同部位的差异。许多与流感病毒成分蛋白相互作用的宿主因子已经被确定,它们在宿主范围扩大和种间传播中的作用正在得到详细的审查。本文综述了受体使用和宿主因子的最新研究进展。
Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin of the previous pandemics results in the close investigation of the mechanism of interspecies transmission. Entry and fusion is the first step for the H5N1 influenza virus to get into the host cells affecting the host ranges. Therefore receptor usage study has been a major focus for the last few years. We now know the difference of the sialic acid structures and distributions in different species, even in the different parts of the same host. Many host factors interacting with the influenza virus component proteins have been identified and their role in the host range expansion and interspecies transmission is under detailed scrutiny. Here we review current progress in the receptor usage and host factors.
流感病毒数据库(IVDB):流感病毒研究的综合信息资源和分析平台。
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