Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms.
Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms.
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DOI：
10.1038/s41467-023-38521-6
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发表时间：
2023-05-17
影响因子：
16.6
通讯作者：
Martin-Duran, Jose M.
中科院分区：
文献类型：
--
作者：
Moggioli, Giacomo;Panossian, Balig;Sun, Yanan;Thiel, Daniel;Martin-Zamora, Francisco M.;Tran, Martin;Clifford, Alexander M.;Goffredi, Shana K.;Rimskaya-Korsakova, Nadezhda;Jekely, Gaspar;Tresguerres, Martin;Qian, Pei-Yuan;Qiu, Jian-Wen;Rouse, Greg W.;Henry, Lee M.;Martin-Duran, Jose M.
细菌共生使环节动物能够在极端的生态环境中定居，比如热液喷口和鲸鱼福尔斯。然而，维持这些共生关系的遗传原理仍然不清楚。在这里，我们表明，不同的基因组适应的基础上共生的遗传相关的环节动物与不同的营养策略。基因组压缩和广泛的基因丢失将食骨蠕虫Osedax frankpressi的异养共生与深海Vestimentifera的化能自养共生区分开来。Osedax的内共生体补充了宿主的许多代谢缺陷，包括失去循环氮和合成一些氨基酸的途径。Osedax的内共生体具有乙醛酸循环，这可以更有效地催化骨源性营养素和从脂肪酸生产碳水化合物。不像大多数Vestimentifera，先天免疫基因在O中减少。然而，Frankpressi具有基质金属蛋白酶的扩增以消化胶原。我们的研究支持，不同的营养相互作用影响宿主基因组进化不同的高度专业化的共生体。由于共生细菌的存在，环节动物蠕虫已经在极端的生态环境中定居，比如热液喷口和鲸鱼福尔斯。这项研究发现，Osedax蠕虫和相关的Vestimentifera已经进化出不同的基因组适应，以维持它们的细菌共生，并利用不同的资源，如腐烂的骨头。
Bacterial symbioses allow annelids to colonise extreme ecological niches, such as hydrothermal vents and whale falls. Yet, the genetic principles sustaining these symbioses remain unclear. Here, we show that different genomic adaptations underpin the symbioses of phylogenetically related annelids with distinct nutritional strategies. Genome compaction and extensive gene losses distinguish the heterotrophic symbiosis of the bone-eating worm Osedax frankpressi from the chemoautotrophic symbiosis of deep-sea Vestimentifera. Osedax’s endosymbionts complement many of the host’s metabolic deficiencies, including the loss of pathways to recycle nitrogen and synthesise some amino acids. Osedax’s endosymbionts possess the glyoxylate cycle, which could allow more efficient catabolism of bone-derived nutrients and the production of carbohydrates from fatty acids. Unlike in most Vestimentifera, innate immunity genes are reduced in O. frankpressi, which, however, has an expansion of matrix metalloproteases to digest collagen. Our study supports that distinct nutritional interactions influence host genome evolution differently in highly specialised symbioses. Annelid worms have colonised extreme ecological niches, such as hydrothermal vents and whale falls thanks to symbiotic bacteria. This study finds that Osedax worms and the related Vestimentifera have evolved different genomic adaptations to sustain their bacterial symbioses and exploit different resources, such as decaying bone.
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影响因子：
4.9
作者：
Bao W;Kojima KK;Kohany O
通讯作者：
Kohany O
影响因子：
2.5
作者：
DeSalvo, Michael K.;Sunagawa, Shinichi;Medina, Monica
通讯作者：
Medina, Monica
DOI：
10.1093/bioinformatics/btp348
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Capella-Gutiérrez S;Silla-Martínez JM;Gabaldón T
通讯作者：
Gabaldón T
影响因子：
3.1
作者：
Bonnivard, Eric;Catrice, Olivier;Higuet, Dominique
通讯作者：
Higuet, Dominique
DOI：
10.1007/978-1-4939-7033-9_1
发表时间：
2017-01-01
期刊：
BACTERIAL PROTEIN SECRETION SYSTEMS
影响因子：
--
作者：
Abby, Sophie S.;Rocha, Eduardo P. C.
通讯作者：
Rocha, Eduardo P. C.