A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota.
A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota.
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DOI：
10.3389/fmicb.2013.00096
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发表时间：
2013
影响因子：
5.2
通讯作者：
Sørum H
中科院分区：
文献类型：
--
作者：
Cantas L;Shah SQ;Cavaco LM;Manaia CM;Walsh F;Popowska M;Garelick H;Bürgmann H;Sørum H
抗菌药物的发现和引入临床医学是20世纪世纪最伟大的医学成就之一，它彻底改变了细菌感染的治疗。然而，由于使用、误用和滥用抗微生物剂而逐渐出现的抗微生物剂抗性病原菌群体如今已成为主要的全球健康问题。抗生素耐药（AMR）基因已被认为起源于环境细菌，因为临床相关的耐药基因已被检测到的染色体上的环境细菌。由于在过去十年中只开发了几种新的抗菌剂，耐药性的进一步演变对公共卫生构成了严重威胁。需要采取紧急措施，不仅要尽量减少用于预防和治疗目的的抗菌剂的使用，而且要寻找控制细菌感染的替代战略。本文综述了全球抗菌素耐药性的情况，有利于其传播的因素，控制策略和限制，以及对所有抗菌素持有者进行持续培训的必要性，即，医学、兽医、公共卫生和其他相关专业人员以及人类消费者，在适当使用抗菌药物方面。
The discovery and introduction of antimicrobial agents to clinical medicine was one of the greatest medical triumphs of the 20th century that revolutionized the treatment of bacterial infections. However, the gradual emergence of populations of antimicrobial-resistant pathogenic bacteria resulting from use, misuse, and abuse of antimicrobials has today become a major global health concern. Antimicrobial resistance (AMR) genes have been suggested to originate from environmental bacteria, as clinically relevant resistance genes have been detected on the chromosome of environmental bacteria. As only a few new antimicrobials have been developed in the last decade, the further evolution of resistance poses a serious threat to public health. Urgent measures are required not only to minimize the use of antimicrobials for prophylactic and therapeutic purposes but also to look for alternative strategies for the control of bacterial infections. This review examines the global picture of antimicrobial resistance, factors that favor its spread, strategies, and limitations for its control and the need for continuous training of all stake-holders i.e., medical, veterinary, public health, and other relevant professionals as well as human consumers, in the appropriate use of antimicrobial drugs.
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影响因子：
4.5
作者：
BJORKLUND, HV;RABERGH, CMI;BYLUND, G
通讯作者：
BYLUND, G
影响因子：
3.2
作者：
Bannoehr, Jeanette;Ben Zakour, Nouri L.;Fitzgerald, J. Ross
通讯作者：
Fitzgerald, J. Ross
影响因子：
4.2
作者：
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通讯作者：
McAllister, Tim A.
影响因子：
4.9
作者：
Aarestrup, FM;Seyfarth, AM;Bager, F
通讯作者：
Bager, F
影响因子：
168.9
作者：
Brown, S;Bantar, C;Amyes, SGB
通讯作者：
Amyes, SGB