Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark.
Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark.
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DOI：
10.1086/591970
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发表时间：
2008-10-15
期刊：
影响因子：
--
通讯作者：
Purcell RH
中科院分区：
文献类型：
--
作者：
Christensen PB;Engle RE;Hjort C;Homburg KM;Vach W;Georgsen J;Purcell RH
戊型肝炎病毒抗体（抗-HEV）在西方国家普遍存在，但临床戊型肝炎很少报告。本研究的目的是确定丹麦献血者和丹麦农民中抗戊型肝炎病毒的流行情况。此外，我们还比较了两组相隔20年的献血者血清样本的患病率。1983年收集的291名丹麦农民和169名献血者的样本和2003年收集的461名献血者的样本进行了抗HEV检测。通过自填式问卷收集HEV暴露的相关信息。在−20°C下储存20年后，对样品进行抗HEV测试。1983年农民抗-HEV阳性率为50.4%，献血员抗-HEV阳性率为32.9%，2003年献血员抗-HEV阳性率为20.6%（P <0.05）。在所有3组中，抗-HEV的存在与年龄的增加显著相关（P <0.05）。在2003年获得血清样本的献血者中，年龄、与马的接触和甲型肝炎病毒抗体的存在与多变量分析中抗-HEV的存在相关。在农民中，只有年龄与抗戊型肝炎病毒的存在独立相关。抗HEV在丹麦人中非常流行，但在过去50年中流行率有所下降。我们的研究支持了丹麦的戊型肝炎病毒感染可能是一种无症状的人畜共患感染的假设。
Antibody to hepatitis E virus (anti-HEV) is prevalent in Western countries, where clinical hepatitis E is rarely reported. The aim of this study was to determine the prevalence of anti-HEV among Danish blood donors and Danish farmers. In addition, we compared the prevalence among 2 sets of serum samples obtained from blood donors 20 years apart. Samples from 291 Danish farmers and 169 blood donors that were collected in 1983 and samples from 461 blood donors that were collected in 2003 were tested for anti-HEV. Relevant information on HEV exposure was collected by self-administered questionnaire. Anti-HEV testing was performed on samples after 20 years of storage at −20°C. The prevalence of anti-HEV was 50.4% among farmers and 32.9% among donors in 1983 and 20.6% among donors in 2003 (P < .05). Presence of anti-HEV was significantly correlated with increasing age in all 3 groups (P < .05). Among donors who had serum samples obtained in 2003, age, contact with horses, and the presence of antibody to hepatitis A virus were associated with the presence of anti-HEV in multivariate analysis. Among farmers, only age was independently associated with the presence of anti-HEV. Anti-HEV was highly prevalent among Danes but has decreased in prevalence over the past 50 years. Our study supports the hypothesis that HEV infection in Denmark may be an asymptomatic zoonotic infection.
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影响因子：
9.4
作者：
Meng, XJ;Wiseman, B;Purcell, RH
通讯作者：
Purcell, RH
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158.5
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Rostaing, Lionel
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5.4
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Olsen, BR;Axelsson-Olsson, D;Weiland, O
通讯作者：
Weiland, O
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2
作者：
Bouwknegt, Martijn;Lodder-Verschoor, Froukje;De Roda Husman, Ana Maria
通讯作者：
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