Altered effective connectivity of the reward network during an incentive-processing task in adults with alcohol use disorder.
Altered effective connectivity of the reward network during an incentive-processing task in adults with alcohol use disorder.
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DOI：
10.1111/acer.14650
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Moeller FG
中科院分区：
文献类型：
--
作者：
Arias AJ;Ma L;Bjork JM;Hammond CJ;Zhou Y;Snyder A;Moeller FG
奖赏敏感性和冲动性的异常与酒精使用障碍（AUD）风险相关，但相关的潜在异常神经回路尚未明确定义。我们试图通过使用功能性神经影像学数据研究AUD患者的激励处理来扩展AUD病理生理学的现有知识。我们利用了来自人类连接组项目数据库的功能性MRI数据，这些数据是在78名DSM-IV酒精滥用或依赖的参与者（合并为AUD组）和78名年龄和性别匹配的对照（CON）参与者中进行数字猜测激励处理任务时获得的。在一个由右半球的前扣带皮层（ACC）、背外侧前额叶皮层（DLPFC）、纹状体、腹侧纹状体和背侧纹状体（DS）组成的网络中，我们进行了动态因果建模分析，以测试由“赢”和“输”条件调制的有效方向连接（EC）的组水平差异（AUD与CON）。我们使用线性回归分析来描述每个EC结果与累积酒精暴露和冲动性措施之间的关系。在获胜期间，AUD参与者从ACC到其他四个节点的EC较低，从DLPFC到其他四个节点的EC较高，从DLPFC到其他四个节点的EC较高，DS到DS自我连接EC高于CON参与者。在总样本中，在胜利过程中，从前额叶到DLPFC（前额叶→ DLPFC）的EC与冲动性（通过延迟折扣任务测量）和累积酒精暴露呈正相关。在胜利期间DS到DS自我连接EC与冲动性呈正相关。从ACC和ACC到其他淋巴结的许多改变的EC与累积的酒精暴露相关。在非酒精奖励反馈期间，AUD患者在工具驱动和自动化皮质纹状体奖励回路中都破坏了EC。这些结果表明，在AUD患者中，皮质纹状体EC在“自上而下”和“自下而上”两种途径中都受到了破坏。
Abnormalities of reward sensitivity and impulsivity are known to be correlated with each other and alcohol use disorder (AUD) risk, but the underlying aberrant neural circuitry involved is not clearly defined. We sought to extend the current knowledge of AUD pathophysiology by studying incentive processing in persons with AUD using functional neuroimaging data. We utilized functional MRI data from the Human Connectome Project Database obtained during performance of a number-guessing incentive-processing task with win, loss, and neutral feedback conditions in 78 participants with either DSM-IV alcohol abuse or dependence (combined as the AUD group) and 78 age- and sex-matched control (CON) participants. Within a network consisting of anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), insula, ventral striatum, and dorsal striatum (DS) in the right hemisphere, we performed dynamic causal modeling analysis to test group-level differences (AUD vs. CON) in effective directional connectivity (EC) as modulated by “win” and “loss” conditions. We used linear regression analyses to characterize the relations between each EC outcome and measures of cumulative alcohol exposure and impulsivity. During wins, AUD participants had lower ECs from ACC to the other four nodes, greater ECs from insula to the other four nodes, greater ECs from DLPFC to the other four nodes, and greater DS to DS self-connection EC than CON participants. In the total sample, EC from the insula to the DLPFC (insula → DLPFC) during wins was positively correlated with both impulsivity (as measured by the delay-discounting task) and cumulative alcohol exposure. The DS to DS self-connection EC during wins was positively correlated with impulsivity. Many of the altered ECs from the ACC and insula to other nodes were correlated with cumulative alcohol exposure. Individuals with AUD have disrupted EC in both instrumentally driven and automatized corticostriatal reward circuits during non-alcohol reward feedback. These results point to disrupted corticostriatal EC in both “top-down” and “bottom-up” pathways among individuals with AUD.
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影响因子：
3.4
作者：
Dick DM;Smith G;Olausson P;Mitchell SH;Leeman RF;O'Malley SS;Sher K
通讯作者：
Sher K
影响因子：
5.7
作者：
Cho, Youngsun T.;Fromm, Stephen;Guyer, Amanda E.;Detloff, Allison;Pine, Daniel S.;Fudge, Julie L.;Ernst, Monique
通讯作者：
Ernst, Monique
DOI：
10.1523/jneurosci.0895-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ballard IC;Murty VP;Carter RM;MacInnes JJ;Huettel SA;Adcock RA
通讯作者：
Adcock RA
影响因子：
4.4
作者：
Dawe, S;Gullo, MJ;Loxton, NJ
通讯作者：
Loxton, NJ
影响因子：
4.8
作者：
Bjork, James M.;Smith, Ashley R.;Chen, Gang;Hommer, Daniel W.
通讯作者：
Hommer, Daniel W.