Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes.
Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes.
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DOI：
10.1021/ja910606y
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发表时间：
2010-03-24
影响因子：
15
通讯作者：
Burdick JA
中科院分区：
文献类型：
--
作者：
Katz JS;Zhong S;Ricart BG;Pochan DJ;Hammer DA;Burdick JA
聚合物囊泡，或聚合物囊泡，是有前途的候选人，在药物输送和组织成像的应用。虽然已经探索了各种各样的聚合物组装成聚合物囊泡的能力，但对于这些聚合物的官能化的研究报道相对较少。我们提出了一种合成聚己内酯-b-聚乙二醇二嵌段共聚物的新方法，该方法允许在嵌段连接处插入官能团并组装功能膜。这种模块化合成是基于固相肽合成技术开发的，并且通过形成两个肽键-在胺封端的PEG和官能团的羧基之间以及在官能团胺和羧基封端的PCL之间实现。作为所得到的囊泡的潜在效用的演示，我们在连接处并入两个不同的氨基酸官能团。2-硝基苯丙氨酸被用来创建UV响应膜，其中囊泡不稳定，并释放封装的内容物照射后。还利用荧光素缀合的赖氨酸来产生稳定的荧光膜，其中荧光被构建到聚合物中。这种方法将有助于我们进一步开发智能功能膜。
Polymer vesicles, or polymersomes, are promising candidates for applications in drug delivery and tissue imaging. While a vast variety of polymers have been explored for their ability to assemble into polymersomes, relatively little research has been reported for studies into the functionalization of these polymers. We present here a novel route to synthesizing poly(caprolactone)-b-poly(ethylene glycol) diblock copolymers that allows for the insertion of functional groups at the blocks’ junction and the assembly of functional membranes. This modular synthesis has been developed based on solid phase peptide synthesis techniques and is accomplished through the formation of two peptide bonds—between an amine terminated PEG and the carboxyl of the functional group and between the functional group amine and a carboxy-terminated PCL. As a demonstration of the potential utility of the resulting vesicles, we incorporated two different amino acid functional groups at the junction. 2-Nitrophenylalanine was utilized to create UV-responsive membranes in which the vesicles destabilized and released encapsulated contents upon irradiation. A fluorescein-conjugated lysine was also utilized to create stable fluorescent membranes in which the fluorescence was built into the polymer. This method should contribute to our ability to further develop smart, functional membranes.
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影响因子：
56.9
作者：
Discher, BM;Won, YY;Hammer, DA
通讯作者：
Hammer, DA
DOI：
10.1073/pnas.0409394102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Ghoroghchian, PP;Frail, PR;Therien, MJ
通讯作者：
Therien, MJ
影响因子：
4.7
作者：
Christian, Natalie A.;Milone, Michael C.;Hammer, Daniel A.
通讯作者：
Hammer, Daniel A.
影响因子：
--
作者：
Zhao, Yue
通讯作者：
Zhao, Yue
影响因子：
3.4
作者：
Hammer, Daniel A.;Robbins, Gregory P.;Bates, Frank S.
通讯作者：
Bates, Frank S.