Does exposure to flame retardants increase the risk for preterm birth?
Does exposure to flame retardants increase the risk for preterm birth?
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暴露于阻燃剂会增加早产的风险吗？
DOI：
10.1016/j.jri.2014.11.002
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发表时间：
2015-02
影响因子：
3.4
通讯作者：
Menon R
中科院分区：
文献类型：
--
作者：
Peltier MR;Koo HC;Getahun D;Menon R
在过去的40年里，多溴联苯醚（PBDEs）被广泛用作阻燃剂，几乎所有妇女都有一定程度的接触。从羊水和脐带血浆中分离出的多溴二苯醚表明存在垂直传播;然而，其对妊娠结果的影响在很大程度上尚不清楚。因此，我们对PBDE-47进行了定量，PBDE-47是在分娩时从随后足月或早产（PTB）的妇女中收集的母体血浆样本中最常见的Conger。然后根据妇女外周血中PBDE-47浓度是否很低、低、中、高或很高对她们进行评分。Probit回归分析表明，PTB组的女性在该量表上得分较高的机会更大（P < 0.001）。PBDE-47浓度高（OR = 3.8，CI：1.6，9.7; P = 0.003）或非常高的妇女比PBDE-47浓度非常低的妇女患肺结核的几率更大（OR = 5.6，CI：2.2，15.2; P < 0.001）。在对母亲的种族、年龄和婚姻状况进行调整后，结果变得更加显著。这些研究结果表明，母亲接触多溴联苯醚的程度高可能会增加患肺结核的风险。
During the past 40 years, polybrominated diphenyl ethers (PBDEs) have been widely used as flame retardants and nearly all women have some level of exposure. PBDEs have been isolated from amniotic fluid and cord plasma indicating vertical transmission; however, their effects on pregnancy outcome are largely unknown. Therefore, we quantified PBDE-47, the most common conger in maternal plasma samples collected at the time of labor from women who subsequently had term or preterm birth (PTB). Women were then scored based on whether or not they had very low, low, medium, high or very high peripheral plasma concentrations of PBDE-47. Probit regression analysis suggested that women in the PTB group had a greater chance of scoring higher on this scale (P < 0.001). Women with high (OR = 3.8, CI: 1.6, 9.7; P = 0.003) or very high PBDE-47 concentrations were at greater odds (OR = 5.6, CI: 2.2, 15.2; P < 0.001) for PTB than women with very low levels of PBDE-47. Results became even more significant after adjustment for maternal race, age, and marital status. These findings suggest that high levels of maternal exposure to PBDEs might increase the risk for PTB.
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影响因子：
3.8
作者：
Peltier, M. R.;Kimova, N. G.;Arita, Y.;Gurzenda, E. M.;Murthy, A.;Chawala, K.;Lerner, V.;Richardson, J.;Hanna, N.
通讯作者：
Hanna, N.
影响因子：
10.4
作者：
Ibhazehiebo K;Iwasaki T;Kimura-Kuroda J;Miyazaki W;Shimokawa N;Koibuchi N
通讯作者：
Koibuchi N
影响因子：
2.5
作者：
Inan, M;Koyuncu, A;Sen, M
通讯作者：
Sen, M
影响因子：
3.6
作者：
SCHONBERGER, W;GRIMM, W;DINKEL, E
通讯作者：
DINKEL, E
影响因子：
8.8
作者：
Shelver, Weilin L.;Parrotta, Carmen D.;Rubio, Fernando M.
通讯作者：
Rubio, Fernando M.