Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.

Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.
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DOI:
10.1289/ehp.7542
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发表时间:
2005-09
影响因子:
10.4
通讯作者:
Working Group for Volume 88
Working Group for Volume 88
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Cogliano VJ;Grosse Y;Baan RA;Straif K;Secretan MB;El Ghissassi F;Working Group for Volume 88

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一个由专家科学家组成的国际跨学科工作组于2004年6月举行会议,编写了关于甲醛、2-丁氧基乙醇和1-叔丁氧基-2-丙醇的国际化学品对人类致癌风险评估专著(IARC专著)。每一本IARC专著都包括对相关科学文献的批判性综述,以及对一种制剂在人类中致癌潜力的评估。在对流行病学、实验和其他相关数据进行彻底讨论后,工作组根据在人类和实验动物中的充分证据得出结论,甲醛对人类是致癌的。在流行病学研究中,有足够的证据表明甲醛会导致鼻咽癌,有“强烈但不充分”的证据证明白血病,有有限的证据表明患有鼻咽癌。工作组还得出结论,2-丁氧基乙醇和1-叔丁氧基-2-丙醇对人类的致癌性不能归类,它们在实验动物身上的证据有限,在人类身上的证据也不充分。这三项评价和支持数据将作为IARC专著第88卷出版。
An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent’s potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, “strong but not sufficient” evidence of leukemia, and limited evidence of sinonasal cancer. The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans. These three evaluations and the supporting data will be-published as Volume 88 of the IARC Monographs.
DOI: 10.1080/15298668591394275
发表时间: 1985-01-01
期刊: AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL
影响因子: --
作者:
HECK, HD;CASANOVASCHMITZ, M;TOSUN, T
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DOI: 10.1093/aje/kwh174
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作者:
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DOI: 10.1007/bf00051411
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影响因子: 2.3
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发表时间: 2003-11-05
影响因子: 10.3
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DOI: 10.1002/ajim.4700200108
发表时间: 1991-07-01
影响因子: 3.5
作者:
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