Post-error recruitment of frontal sensory cortical projections promotes attention in mice.
Post-error recruitment of frontal sensory cortical projections promotes attention in mice.
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DOI：
10.1016/j.neuron.2021.02.001
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发表时间：
2021-04-07
期刊：
影响因子：
16.2
通讯作者：
Morishita H
中科院分区：
文献类型：
--
作者：
Norman KJ;Riceberg JS;Koike H;Bateh J;McCraney SE;Caro K;Kato D;Liang A;Yamamuro K;Flanigan ME;Kam K;Falk EN;Brady DM;Cho C;Sadahiro M;Yoshitake K;Maccario P;Demars MP;Waltrip L;Varga AW;Russo SJ;Baxter MG;Shapiro ML;Rudebeck PH;Morishita H
额叶皮层，特别是前扣带皮层区（ACA），是必不可少的施加错误后的认知控制，但机制，使注意力的调制，以提高错误后的性能知之甚少。在这里，我们证明，在小鼠视觉注意任务，ACA神经元投射到视觉皮层（维斯; ACA维斯）最近的错误选择性地招募。光遗传学操纵这一途径共同支持的节奏调制ACAVIS投射神经元的预期视觉刺激是至关重要的调整性能错误。麻醉小鼠中ACA维斯的30 Hz光遗传学刺激重现了与行为期间的内源性错误后表现相关的增加的γ和减少的θ维斯振荡变化，以及随后增加的视觉诱发尖峰，视觉注意力的标志性特征。这种额叶感觉神经回路将错误监测与实施注意力调整联系起来，以指导行为适应，指出了促进认知控制的基于回路的机制。诺曼等al发现，行为错误会引起小鼠的额感觉投射。该途径的30 Hz光遗传学刺激调节行为小鼠错误后的表现，并概括麻醉小鼠注意力的神经生理学标志。因此，额叶感觉投射将错误监控与行为适应的注意力调整联系起来。
The frontal cortex, especially the anterior cingulate cortex area (ACA), is essential for exerting cognitive control after errors, but the mechanisms that enable the modulation of attention to improve performance after errors are poorly understood. Here, we demonstrate that during a mouse visual attention task, ACA neurons projecting to the visual cortex (VIS; ACAVIS) are recruited selectively by recent errors. Optogenetic manipulations of this pathway collectively support that rhythmic modulation of ACAVIS projection neurons in anticipation of visual stimuli is crucial for adjusting performance following errors. 30Hz optogenetic stimulation of ACAVIS in anesthetized mice recapitulates the increased gamma and reduced theta VIS oscillatory changes that are associated with endogenous post-error performance during behavior, and subsequently increased visual-evoked spiking, a hallmark feature of visual attention. This frontal-sensory neural circuit links error monitoring with implementing adjustments of attention to guide behavioral adaptation, pointing to a circuit-based mechanism for promoting cognitive control. Norman et. al found that behavioral errors recruit frontal-sensory projections in mice. 30 Hz optogenetic stimulation of this pathway modulates performance following errors in behaving mice, and recapitulates neurophysiological hallmarks of attention in anesthetized mice. Frontal-sensory projections thereby link error monitoring with attention adjustments for behavioral adaptation.
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