The Structural Connectome and Internalizing and Externalizing Symptoms at 7 and 13 Years in Individuals Born Very Preterm and Full Term.
The Structural Connectome and Internalizing and Externalizing Symptoms at 7 and 13 Years in Individuals Born Very Preterm and Full Term.
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DOI：
10.1016/j.bpsc.2021.10.003
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Anderson PJ
中科院分区：
文献类型：
--
作者：
Gilchrist CP;Thompson DK;Kelly CE;Beare R;Adamson C;Dhollander T;Lee K;Treyvaud K;Matthews LG;Tolcos M;Cheong JLY;Inder TE;Doyle LW;Cumberland A;Anderson PJ
Children born very preterm (VP) are at higher risk of emotional and behavioral problems compared with full-term (FT) children. We investigated the neurobiological basis of internalizing and externalizing symptoms in individuals born VP and FT by applying a graph theory approach. Structural and diffusion MRI data were combined to generate structural connectomes and calculate measures of network integration and segregation at 7 (VP:72; FT:17) and 13 years (VP:125; FT:44). Internalizing and externalizing were assessed at 7 and 13 years using the Strengths and Difficulties Questionnaire. Linear regression models were used to relate network measures and internalizing and externalizing symptoms concurrently at 7 and 13 years. Lower network integration (characteristic path length and global efficiency) was associated with higher internalizing symptoms in VP and FT children at 7 years, but not at 13 years. The association between network integration (characteristic path length) and externalizing symptoms at 7 years was weaker, but there was some evidence for differential associations between groups, with lower integration in the VP and higher integration in the FT group associated with higher externalizing symptoms. At 13 years, there was some evidence that associations between network segregation (average clustering coefficient, transitivity, local efficiency) and externalizing differed between the VP and FT groups, with stronger positive associations in the VP group. This study provides insights into the neurobiological basis of emotional and behavioral problems following preterm birth, highlighting the role of the structural connectome in internalizing and externalizing symptoms in childhood and adolescence.
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影响因子：
2.9
作者：
Cismaru AL;Gui L;Vasung L;Lejeune F;Barisnikov K;Truttmann A;Borradori Tolsa C;Hüppi PS
通讯作者：
Hüppi PS
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
5.7
作者：
Bastiani M;Cottaar M;Fitzgibbon SP;Suri S;Alfaro-Almagro F;Sotiropoulos SN;Jbabdi S;Andersson JLR
通讯作者：
Andersson JLR
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
10.9
作者：
Avants, B. B.;Epstein, C. L.;Gee, J. C.
通讯作者：
Gee, J. C.