SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals.

SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naïve and previously infected individuals.
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DOI:
10.1016/j.jiph.2021.07.005
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发表时间:
2021-08
影响因子:
6.7
通讯作者:
Gori A
Gori A
中科院分区:
医学3区
文献类型:
--
作者:
Lombardi A;Consonni D;Oggioni M;Bono P;Uceda Renteria S;Piatti A;Pesatori AC;Castaldi S;Muscatello A;Riboldi L;Ceriotti F;Bandera A;Gori A

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人们对控制新冠肺炎大流行的疫苗寄予厚望。我们回顾了一组接种了BNT162b2疫苗的医护人员(HCW)的抗体滴度,以评估先前感染对他们的影响。我们根据鼻咽拭子(NPS)和症状的个体病史对结果进行分层。在3475名卫生工作者中,接种前6个月以上感染者的滴度最高,其次是接种前6个月以内的感染者,特别是有症状的感染者和未感染的卫生工作者。接种BNT162b2疫苗可以提高通过感染获得的免疫力,特别是在接种疫苗前6个月以上感染的人。
Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed the antibody titres in a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 to assess the influence of a previous infection on them. We stratified the results according to the individual history of nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs the highest titres were recorded among those infected more than 6 months before vaccination, independently of symptoms, followed by those infected less than 6 months before vaccination, especially in those with symptoms, and by uninfected HCWs. Vaccination with BNT162b2 can boost immunity acquired through infection, particularly in those infected more than 6 months before vaccination.
DOI: 10.1038/s41591-021-01325-6
发表时间: 2021-06
期刊: Nature medicine
影响因子: 82.9
作者:
Ebinger JE;Fert-Bober J;Printsev I;Wu M;Sun N;Prostko JC;Frias EC;Stewart JL;Van Eyk JE;Braun JG;Cheng S;Sobhani K
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Lumley SF;O'Donnell D;Stoesser NE;Matthews PC;Howarth A;Hatch SB;Marsden BD;Cox S;James T;Warren F;Peck LJ;Ritter TG;de Toledo Z;Warren L;Axten D;Cornall RJ;Jones EY;Stuart DI;Screaton G;Ebner D;Hoosdally S;Chand M;Crook DW;O'Donnell AM;Conlon CP;Pouwels KB;Walker AS;Peto TEA;Hopkins S;Walker TM;Jeffery K;Eyre DW;Oxford University Hospitals Staff Testing Group
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通讯作者: Blomberg BB
DOI: 10.1016/j.cmi.2020.06.013
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Lombardi, A.;Consonni, D.;Gori, A.
通讯作者: Gori, A.
肥胖与人类流感疫苗接种的免疫反应受损有关。
DOI: 10.1038/ijo.2011.208
发表时间: 2012-08
影响因子: 4.9
作者:
Sheridan, P. A.;Paich, H. A.;Handy, J.;Karlsson, E. A.;Hudgens, M. G.;Sammon, A. B.;Holland, L. A.;Weir, S.;Noah, T. L.;Beck, M. A.
通讯作者: Beck, M. A.