High trait anxiety during adolescence interferes with discriminatory context learning.
High trait anxiety during adolescence interferes with discriminatory context learning.
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青春期的高特质焦虑会干扰歧视性情境学习。
DOI：
10.1016/j.nlm.2015.05.002
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发表时间：
2015-09
影响因子：
2.7
通讯作者：
Lau JY
中科院分区：
文献类型：
--
作者：
Cohen Kadosh K;Haddad AD;Heathcote LC;Murphy RA;Pine DS;Lau JY
持续性成人焦虑症通常开始于青春期。随着对早期治疗的重视，我们需要更好地了解青少年焦虑是如何发展的。在本研究中，我们使用了恐惧条件化范式，以确定中断线索和背景威胁学习的19个高焦虑（HA）和24个低焦虑（LA）的青少年（12-17岁）。我们提出了三个中性的女性面孔（条件刺激，CS）在三个条件刺激（UCS，尖叫的女性尖叫）在三个虚拟房间的情况下，在三个偶然的关系。CS和UCS之间的偶然性程度在不同的房间里有所不同：在可预测的尖叫条件下，尖叫跟随着100%的试验;在不可预测的尖叫条件下，尖叫和脸随机出现，彼此独立;在没有尖叫的条件下，CS在没有任何UCS的情况下出现。我们发现，洛杉矶青少年表现出更高水平的恐惧增强惊吓的脸相对于房间。这种差异是独立的应急条件。HA青少年表现出非差分惊吓CS之间，但是，在以前的成人数据相反，在这两种线索类型显示最低惊吓的不可预测的条件和最高惊吓的无尖叫条件。我们的研究是第一个检查青少年的背景条件反射，我们的研究结果表明，在发展早期的高特质焦虑可能与无法消除线索和背景的信号作用，以及错误标记的安全或模糊的信号。
Persistent adult anxiety disorders often begin in adolescence. As emphasis on early treatment grows, we need a better understanding of how adolescent anxiety develops. In the current study, we used a fear conditioning paradigm to identify disruptions in cue and context threat-learning in 19 high anxious (HA) and 24 low anxious (LA) adolescents (12–17 years). We presented three neutral female faces (conditioned stimulus, CS) in three contingent relations with an unconditioned stimulus (UCS, a shrieking female scream) in three virtual room contexts. The degree of contingency between the CSs and the UCSs varied across the rooms: in the predictable scream condition, the scream followed the face on 100% of trials; in the unpredictable scream condition, the scream and face appeared randomly and independently of each other; in the no-scream condition the CS was presented in the absence of any UCS. We found that the LA adolescents showed higher levels of fear-potentiated startle to the faces relative to the rooms. This difference was independent of the contingency condition. The HA adolescents showed non-differential startle between the CSs, but, in contrast to previous adult data, across both cue types displayed lowest startle to the unpredictable condition and highest startle to the no-scream condition. Our study is the first to examine context conditioning in adolescents, and our results suggest that high trait anxiety early in development may be associated with an inability to disambiguate the signalling roles of cues and contexts, and a mislabelling of safety or ambiguous signals.
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影响因子：
2.7
作者：
Brasser, SM;Spear, NE
通讯作者：
Spear, NE
影响因子：
4.1
作者：
Lissek S;Rabin SJ;McDowell DJ;Dvir S;Bradford DE;Geraci M;Pine DS;Grillon C
通讯作者：
Grillon C
影响因子：
8.2
作者：
Löw A;Lang PJ;Smith JC;Bradley MM
通讯作者：
Bradley MM
影响因子：
10.6
作者：
Grillon, C
通讯作者：
Grillon, C
影响因子：
4.6
作者：
HAMM, AO;VAITL, D;LANG, PJ
通讯作者：
LANG, PJ