An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.
An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.
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一个扩展的杏仁核-中脑回路控制可卡因戒断引起的焦虑和恢复。
DOI：
10.1016/j.celrep.2022.110775
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发表时间：
2022-05-03
期刊：
影响因子：
8.8
通讯作者：
Beier, Kevin T.
中科院分区：
文献类型：
--
作者：
Tian, Guilian;Hui, May;Macchia, Desiree;Derdeyn, Pieter;Rogers, Alexandra;Hubbard, Elizabeth;Liu, Chengfeng;Vasquez, Jose J.;Taniguchi, Lara;Bartas, Katrina;Carroll, Sean;Beier, Kevin T.
虽然中脑多巴胺(DA)回路是动机行为的核心，但我们对经验如何修改这些回路以促进后续行为适应的了解有限。在这里，我们展示了腹侧被盖区DA投射到杏仁核(VTADA→杏仁核)对于可卡因诱导的焦虑的选择性作用，而不是可卡因的奖赏或敏化。我们的狂犬病病毒介导的电路作图方法显示，来自终纹床核的抑制性GABA能细胞和下游的VTADA→杏仁核细胞的自发和任务相关活动持续增加，即使在单一可卡因暴露后也可以检测到这些细胞。BNSTGABA→中脑细胞的活动与可卡因诱导的焦虑有关，但与奖赏或敏化无关，抑制这一投射可防止可卡因长期戒断期间焦虑的发展。最后，我们观察到VTADA→杏仁核细胞在挑战可卡因暴露后被强烈激活，这些细胞中的活动是恢复可卡因地点偏爱的必要条件和充分条件。田等人研究表明，BNSTGABA→中脑细胞活性的升高与单一可卡因暴露后表现出的戒断焦虑有关。抑制或激活BNSTGABA、→、VTADA、→杏仁核通路可双向控制可卡因诱导的戒断焦虑。VTADA→杏仁核细胞的激活也足以推动可卡因诱导的位置偏爱的强劲恢复。
Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a ventral tegmental area DA projection to the amygdala (VTADA→amygdala) for cocaine-induced anxiety but not cocaine reward or sensitization. Our rabies virus-mediated circuit mapping approach reveals a persistent elevation in spontaneous and task-related activity of inhibitory GABAergic cells from the bed nucleus of the stria terminalis (BNST) and downstream VTADA→amygdala cells that can be detected even after a single cocaine exposure. Activity in BNSTGABA→midbrain cells is related to cocaine-induced anxiety but not reward or sensitization, and silencing this projection prevents development of anxiety during protracted withdrawal after cocaine administration. Finally, we observe that VTADA→amygdala cells are strongly activated after a challenge exposure to cocaine and that activity in these cells is necessary and sufficient for reinstatement of cocaine place preference. Tian et al. show that an elevation of BNSTGABA→midbrain cell activity is related to withdrawal anxiety that manifests after a single cocaine exposure. Inhibition or activation of the BNSTGABA→ VTADA→amygdala pathway bidirectionally controls cocaine-induced withdrawal anxiety. Activation of VTADA→amygdala cells is also sufficient to drive robust reinstatement of cocaine-induced place preference.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
2.5
作者：
Dong, HW;Swanson, LW
通讯作者：
Swanson, LW
DOI：
10.1016/j.pnpbp.2009.07.010
发表时间：
2009-11-13
影响因子：
5.6
作者：
Jalabert, Marion;Aston-Jones, Gary;Herzog, Etienne;Manzoni, Olivier;Georges, Francois
通讯作者：
Georges, Francois
影响因子：
3.4
作者：
Francesconi W;Szücs A;Berton F;Koob GF;Vendruscolo LF;Sanna PP
通讯作者：
Sanna PP
影响因子：
16.2
作者：
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide