Cellular signaling perturbation by natural products.
Cellular signaling perturbation by natural products.
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DOI：
10.1016/j.cellsig.2009.03.009
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发表时间：
2009-11
影响因子：
4.8
通讯作者：
Kong D
中科院分区：
文献类型：
--
作者：
Sarkar FH;Li Y;Wang Z;Kong D
Cancer cells are known to have alterations in multiple cellular signaling pathways and because of the complexities in the communication between multiple signaling networks, the treatment and the cure for most human malignancies is still an open question. Perhaps, this is the reason why specific inhibitors that target only one pathway have been typically failed in cancer treatment. However, the in vitro and in vivo studies have demonstrated that some natural products such as isoflavones, indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM), curcumin, (−)-epigallocatechin-3-gallate (EGCG), resveratrol, lycopene, etc, have inhibitory effects on human and animal cancers through targeting multiple cellular signaling pathways and thus these “natural agents” could be classified as multi-targeted agents. This is also consistent with the epidemiological studies showing that the consumption of fruits, soybean and vegetables is associated with reduced risk of several types of cancers. By regulating multiple important cellular signaling pathways including NF-κB, Akt, MAPK, Wnt, Notch, p53, AR, ER, etc, these natural products are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells. Therefore, non-toxic “natural agents” harvested from the bounties of nature could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
DOI：
10.1016/s0925-4439(03)00082-6
发表时间：
2003-07-14
影响因子：
6.2
作者：
Chen, WF;Huang, MH;Wong, MS
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Wong, MS
影响因子：
7.4
作者：
Davis, JN;Kucuk, O;Sarkar, FH
通讯作者：
Sarkar, FH
(-)-表没食子儿茶素-3-没食子酸酯在 LNCaP 前列腺癌细胞不同进展阶段抑制雄激素受体信号传导和前列腺特异性抗原表达。
影响因子：
9.7
作者：
Chuu, Chih-Pin;Chen, Rou-Yu;Kokontis, John M.;Hiipakka, Richard A.;Liao, Shutsung
通讯作者：
Liao, Shutsung
影响因子：
8
作者：
Afaq, F;Adhami, VM;Mukhtar, H
通讯作者：
Mukhtar, H