Cortical Source Analysis of Event-Related Potentials: A Developmental Approach.
Cortical Source Analysis of Event-Related Potentials: A Developmental Approach.
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DOI:
10.1016/j.dcn.2022.101092
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发表时间:
2022-04
影响因子:
4.7
通讯作者:
Richards JE
中科院分区:
文献类型:
--
作者:
Conte S;Richards JE
Cortical source analysis of electroencephalographic (EEG) signals has become an important tool in the analysis of brain activity. The aim of source analysis is to reconstruct the cortical generators (sources) of the EEG signal recorded on the scalp. The quality of the source reconstruction relies on the accuracy of the forward problem, and consequently the inverse problem. An accurate forward solution is obtained when an appropriate imaging modality (i.e., structural magnetic resonance imaging – MRI) is used to describe the head geometry, precise electrode locations are identified with 3D maps of the sensor positions on the scalp, and realistic conductivity values are determined for each tissue type of the head model. Together these parameters contribute to the definition of realistic head models. Here, we describe the steps necessary to reconstruct the cortical generators of the EEG signal recorded on the scalp. We provide an example of source reconstruction of event-related potentials (ERPs) during a face-processing task performed by a 6-month-old infant. We discuss the adjustments necessary to perform source analysis with measures different from the ERPs. The proposed pipeline can be applied to the investigation of different cognitive tasks in both younger and older participants. Source analysis can overcome the limited spatial resolution of EEG data Localization errors are reduced with realistic head models and electrode locations ERP generators were localized on individual, close, and age-appropriate volumes Anatomical ROIs improved signal-to-noise ratio and reduced family-wise error rates
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