Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project.
Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project.
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DOI：
10.1136/gut.2010.236026
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发表时间：
2012-07
期刊：
影响因子：
24.5
通讯作者：
Iacobuzio-Donahue CA
中科院分区：
文献类型：
--
作者：
Iacobuzio-Donahue CA
胰腺癌是一种由特定基因的遗传改变积累引起的疾病。人类基因组序列的阐明，结合进行全外显子组测序能力的技术进步，为这种致命肿瘤类型的突变谱特征提供了新的见解。最近，外显子组测序已被用于阐明胰腺癌的克隆进化以及提供胰腺癌发生的时间估计，这表明在治愈阶段早期检测这种疾病可能存在很长的机会窗口。展望未来，这些突变分析表明了个性化诊断和治疗干预的潜在靶点，以及基于胰腺癌发生和进展的自然史进行干预的最佳时机。
Pancreatic cancer is a disease caused by the accumulation of genetic alterations in specific genes. Elucidation of the human genome sequence, in conjunction with technical advances in the ability to perform whole exome sequencing, have provided new insight into the mutational spectra characteristic of this lethal tumour type. Most recently, exomic sequencing has been used to clarify the clonal evolution of pancreatic cancer as well as provide time estimates of pancreatic carcinogenesis, indicating that a long window of opportunity may exist for early detection of this disease while in the curative stage. Moving forward, these mutational analyses indicate potential targets for personalised diagnostic and therapeutic intervention as well as the optimal timing for intervention based on the natural history of pancreatic carcinogenesis and progression.
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作者：
Embuscado, EE;Laheru, D;Iacobuzio-Donahue, CA
通讯作者：
Iacobuzio-Donahue, CA
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