Alcohol use is not a significant contributor to myelodysplastic syndromes.
Alcohol use is not a significant contributor to myelodysplastic syndromes.
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DOI：
10.1007/s10552-020-01298-w
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Poynter JN
中科院分区：
文献类型：
--
作者：
Duffy EA;Nguyen PL;Cioc A;Warlick E;Roesler MA;Poynter JN
Myelodysplastic syndromes (MDS) are a class of clonal neoplastic disorders of largely unknown etiology, and published data remain inconclusive regarding the association between lifetime alcohol consumption and MDS risk. In these analyses, data from a population-based case-control study were used to investigate this association. Eligible cases of MDS were identified through the Minnesota Cancer Reporting System; controls were matched by sex and age-decile. A central review process was used to confirm MDS diagnosis and classify subtypes. Unconditional and polytomous logistic regression were used to calculate odds ratios (OR) and 95% confidence intervals (CI). Kaplan-Meier curves were used to compare survival by category of lifetime alcohol consumption. In total, 398 cases of MDS and 698 controls were included. Alcohol consumption at 23–30, 31–49, and 50–65 years of age, recent consumption 1 year before diagnosis/interview, and lifetime consumption were not found to be significantly associated with MDS in males (OR range 0.63–0.99) or females (OR range 0.58–1.70). Analysis by MDS subtype further suggested there was not a significant association between recent alcohol consumption and odds of disease by subtype (OR range 0.39–1.13). Lifetime alcohol consumption was not significantly associated with survival after diagnosis of MDS Previously reported associations between alcohol consumption and MDS risk were inconsistent. Results from our analyses by sex and disease subtype do not support alcohol as a significant contributor to risk for MDS.
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影响因子：
2.7
作者：
BROWN, LM;GIBSON, R;BLAIR, A
通讯作者：
BLAIR, A
影响因子：
5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1007/978-3-319-09614-8_20
发表时间：
2015-01-01
期刊：
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影响因子：
--
作者：
Smith, Clay;Gasparetto, Maura;Vasiliou, Vasilis
通讯作者：
Vasiliou, Vasilis
影响因子：
5.9
作者：
Ma, Xiaomei
通讯作者：
Ma, Xiaomei