Divergent and convergent evolution of housekeeping genes in human-pig lineage.
Divergent and convergent evolution of housekeeping genes in human-pig lineage.
复制标题
人猪谱系中看家基因的趋异与趋同进化
作者：
Wei K;Zhang T;Ma L
管家基因在组织/细胞类型条件下普遍表达并维持基本细胞功能。本研究的目的是开发一套猪管家基因，并比较管家基因在人-猪谱系中的结构、进化和功能。通过使用RNA测序数据，我们鉴定了3，136个猪管家基因。与人类管家基因相比，我们发现猪管家基因更长，受到的净化选择压力稍弱，中性进化更快。由两个物种共享的共同管家基因比物种特异性基因实现更强的净化选择。然而，猪和人类特有的管家基因具有相似的功能。一些物种特异性管家基因已经独立进化，形成类似的蛋白质活性位点或结构，如经典的催化丝氨酸-组氨酸-天冬氨酸三联体，这意味着它们已经收敛，以维持基本的细胞功能，这使得它们能够适应环境。人类和猪的管家基因具有不同的结构和基因列表，但它们都集中在维持细胞存在所必需的基本细胞功能上，而不管其在物种中的具体作用如何。我们的研究结果揭示了管家基因的进化动力学。
Housekeeping genes are ubiquitously expressed and maintain basic cellular functions across tissue/cell type conditions. The present study aimed to develop a set of pig housekeeping genes and compare the structure, evolution and function of housekeeping genes in the human–pig lineage. By using RNA sequencing data, we identified 3,136 pig housekeeping genes. Compared with human housekeeping genes, we found that pig housekeeping genes were longer and subjected to slightly weaker purifying selection pressure and faster neutral evolution. Common housekeeping genes, shared by the two species, achieve stronger purifying selection than species-specific genes. However, pig- and human-specific housekeeping genes have similar functions. Some species-specific housekeeping genes have evolved independently to form similar protein active sites or structure, such as the classical catalytic serine–histidine–aspartate triad, implying that they have converged for maintaining the basic cellular function, which allows them to adapt to the environment. Human and pig housekeeping genes have varied structures and gene lists, but they have converged to maintain basic cellular functions essential for the existence of a cell, regardless of its specific role in the species. The results of our study shed light on the evolutionary dynamics of housekeeping genes.
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影响因子：
3.7
作者：
de Jonge HJ;Fehrmann RS;de Bont ES;Hofstra RM;Gerbens F;Kamps WA;de Vries EG;van der Zee AG;te Meerman GJ;ter Elst A
通讯作者：
ter Elst A
影响因子：
4.4
作者：
Bellora N;Farré D;Albà MM
通讯作者：
Albà MM
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1016/j.bbrc.2013.07.074
发表时间：
2013-08-23
影响因子：
3.1
作者：
Farajzadeh, Leila;Hornshoj, Henrik;Madsen, Lone Bruhn
通讯作者：
Madsen, Lone Bruhn
影响因子：
2.2
作者：
Greer, Samantha;Honeywell, Rice;Raptis, Leda
通讯作者：
Raptis, Leda