P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology.
P3 amplitude reductions are associated with shared variance between internalizing and externalizing psychopathology.
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DOI：
10.1111/psyp.13618
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发表时间：
2020-07
期刊：
影响因子：
3.7
通讯作者：
Hicks BM
中科院分区：
文献类型：
--
作者：
Bernat EM;Ellis JS;Bachman MD;Hicks BM
P3波幅降低通常在古怪的范式中引起，与内化(例如抑郁和焦虑)和外化问题(例如物质使用、攻击性、冲动)有关。最近的因素分析模型已经集中在内在化和外在化问题之间的共同差异，作为潜在的重要的精神病理学构造。为了评估这种共同差异的神经生理学标记，我们检查了具有一系列内化和外化问题的本科生样本中的P3波幅与靶点和新刺激的关系。参与者(N=125)完成了一个旋转头部的古怪视觉范式，IAPS图片作为不常见的新刺激。结果对于内化和外化问题，分别复制了相对于目标刺激和新刺激的P3波幅降低，发现内化和外化问题的共同方差与小说、靶子的P3波幅降低以及目标和新奇P3测量的因子分显著相关。本研究结果与一般的或共同的问题行为因素解释了P3波幅降低与内化和外化问题之间的大部分联系。
P3 amplitude reductions, commonly elicited in oddball paradigms, have been associated with both internalizing (e.g., depression and anxiety) and externalizing problems (e.g., substance use, aggression, impulsivity). Recent factor analytic models have focused on the shared variance between internalizing and externalizing problems as a potentially important psychopathology construct. To assess neurophysiological markers of this shared variance, we examined P3 amplitude to target and novel stimuli in an undergraduate sample with a range of internalizing and externalizing problems. Participants (N = 125) completed a rotated heads visual oddball paradigm, with IAPS pictures serving as infrequent novel stimuli. Results replicated P3 amplitude reduction relative to both target and novel stimuli separately for internalizing and externalizing problems, and found that the shared variance across internalizing and externalizing was significantly related to lower P3 amplitude to novels, targets, and a factor score of target and novel P3 measures. The present results are consistent with the interpretation that a general or shared problem behavior factor accounts for much of the associations between reduced P3 amplitude and internalizing and externalizing problems.
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影响因子：
4.6
作者：
Bernat, Edward M.;Nelson, Lindsay D.;Steele, Vaughn R.;Gehring, William J.;Patrick, Christopher J.
通讯作者：
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通讯作者：
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影响因子：
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作者：
Cosgrove, Victoria E.;Rhee, Soo H.;Gelhorn, Heather L.;Boeldt, Debra;Corley, Robin C.;Ehringer, Marissa A.;Young, Susan E.;Hewitt, John K.
通讯作者：
Hewitt, John K.