Adult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicus
Adult neurogenesis in the brain of the Mozambique tilapia, Oreochromis mossambicus
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莫桑比克罗非鱼 Oreochromis mossambicus 大脑中成体神经发生
DOI：
--
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
G. Zupanc
中科院分区：
文献类型：
--
作者：
Magda C. Teles;R. F. Sîrbulescu;U. Wellbrock;Rui F. Oliveira;G. Zupanc
虽然近年来对成年神经系统中新神经元的产生（“成年神经发生”）进行了深入研究，但对非哺乳类脊椎动物中的这种现象知之甚少。在这里，我们研究了新的神经元和神经胶质细胞在莫桑比克罗非鱼（Oreochromis mossambicus），最大的脊椎动物分类的一个代表，鲈形鱼的产生，迁移和分化。大脑中绝大多数的新细胞产生于嗅球的特定增殖区;端脑的背侧和腹侧;间脑的后结节的室周核、视顶盖和外侧隐窝核;以及小脑的小脑瓣、小脑体和尾叶。如嗅球和小脑瓣的外侧部分所示，一些年轻细胞从它们的起源部位迁移到特定的目标区域。用胸苷类似物5-溴-2 ′-脱氧尿苷标记有丝分裂细胞，结合针对神经元特异性标志物蛋白Hu或针对星形胶质细胞标志物胶质细胞酸性蛋白的免疫染色，证明了成体细胞分化为神经元和胶质细胞。两者合计，本研究支持的假设，成年神经发生是一个进化保守的脊椎动物性状。
Although the generation of new neurons in the adult nervous system (‘adult neurogenesis’) has been studied intensively in recent years, little is known about this phenomenon in non-mammalian vertebrates. Here, we examined the generation, migration, and differentiation of new neurons and glial cells in the Mozambique tilapia (Oreochromis mossambicus), a representative of one of the largest vertebrate taxonomic orders, the perciform fish. The vast majority of new cells in the brain are born in specific proliferation zones of the olfactory bulb; the dorsal and ventral telencephalon; the periventricular nucleus of the posterior tuberculum, optic tectum, and nucleus recessi lateralis of the diencephalon; and the valvula cerebelli, corpus cerebelli, and lobus caudalis of the cerebellum. As shown in the olfactory bulb and the lateral part of the valvula cerebelli, some of the young cells migrate from their site of origin to specific target areas. Labeling of mitotic cells with the thymidine analog 5-bromo-2′-deoxyuridine, combined with immunostaining against the neuron-specific marker protein Hu or against the astroglial marker glial fibrillary acidic protein demonstrated differentiation of the adult-born cells into both neurons and glia. Taken together, the present investigation supports the hypothesis that adult neurogenesis is an evolutionarily conserved vertebrate trait.
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神经嵴谱系中早期神经源性细胞的鉴定。
影响因子：
2.7
作者：
Marusich,MF;Weston,JA
通讯作者：
Weston,JA
影响因子：
5.3
作者：
Kaslin, Jan;Ganz, Julia;Brand, Michael
通讯作者：
Brand, Michael
影响因子：
2.7
作者：
Grandel, Heiner;Kaslin, Jan;Brand, Michael
通讯作者：
Brand, Michael
DOI：
10.1073/pnas.96.9.5263
发表时间：
1999-04-27
影响因子：
11.1
作者：
Gould, E;Reeves, AJ;Fuchs, E
通讯作者：
Fuchs, E