Cell cycle regulation of Golgi membrane dynamics.
Cell cycle regulation of Golgi membrane dynamics.
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DOI:
10.1016/j.tcb.2013.01.008
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发表时间:
2013-06
影响因子:
19
通讯作者:
Wang, Yanzhuang
中科院分区:
文献类型:
--
作者:
Tang, Danming;Wang, Yanzhuang
The Golgi apparatus is a membranous organelle in the cell that plays essential roles in protein and lipid trafficking, sorting, processing and modification. Its basic structure is a stack of closely aligned flattened cisternae. In mammalian cells, dozens of Golgi stacks are often laterally linked into a ribbon-like structure. Biogenesis of the Golgi during cell division occurs through a sophisticated disassembly and reassembly process that can be divided into three distinct but cooperative steps, including the deformation and reformation of the Golgi cisternae, stacks and ribbon. Here, we review our current understanding of the protein machineries that control these three steps in the cycle of mammalian cell division: GRASP65 and GRASP55 in Golgi stack and ribbon formation; ubiquitin and AAA ATPases in post-mitotic Golgi membrane fusion; and golgins and cytoskeleton in Golgi ribbon formation.
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