X chromosome regulation: diverse patterns in development, tissues and disease.
X chromosome regulation: diverse patterns in development, tissues and disease.
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DOI：
10.1038/nrg3687
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发表时间：
2014-06
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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Genes on the mammalian X chromosome are present in one copy in males and two copies in females. The complex mechanisms that regulate the X chromosome lead to evolutionary and physiological variability in gene expression between species, the sexes, individuals, developmental stages, tissues and cell types. In early development, delayed and incomplete X chromosome inactivation (XCI) in some species causes variability in gene expression. Additional diversity stems from escape from XCI and from mosaicism or XCI skewing in females. This causes sex-specific differences that manifest as differential gene expression and associated phenotypes. Furthermore, the complexity and diversity of X dosage regulation affect the severity of diseases caused by X-linked mutations.
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影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
DOI：
10.1159/000133152
发表时间：
1991-01-01
期刊：
CYTOGENETICS AND CELL GENETICS
影响因子：
--
作者：
EICHER, EM;HALE, DW;WASHBURN, LL
通讯作者：
WASHBURN, LL
影响因子：
12.3
作者：
Al Nadaf, Shafagh;Waters, Paul D.;Graves, Jennifer A. M.
通讯作者：
Graves, Jennifer A. M.
影响因子：
56.9
作者：
Duret, L;Chureau, C;Avner, P
通讯作者：
Avner, P
影响因子：
5.3
作者：
Anderson, CL;Brown, CJ
通讯作者：
Brown, CJ