Up-to-date approach to manage keloids and hypertrophic scars: a useful guide.
Up-to-date approach to manage keloids and hypertrophic scars: a useful guide.
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DOI：
10.1016/j.burns.2014.02.011
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Jeschke MG
中科院分区：
文献类型：
--
作者：
Arno AI;Gauglitz GG;Barret JP;Jeschke MG
瘢痕疙瘩和增生性瘢痕发生在30%至90%的患者中，其特征在于病理性过度真皮纤维化和异常伤口愈合。这两种实体具有不同的临床和组织化学特征，不幸的是，由于缺乏有效的治疗方法，这仍然是临床医生面临的巨大挑战。目前分子生物学和遗传学的进展揭示了新的预防和治疗选择，这代表了管理这一高度流行的慢性和致残性问题的希望，具有长期有益的结果和生活质量的改善。然而，在我们等待这些转化临床产品上市的同时，我们必须了解目前现有的各种治疗过度疤痕的策略的基础知识：从经典的皮质疗法到最新的肉毒杆菌毒素和激光。本文的主要目的是提供一个有用的最新指南，以预防和治疗瘢痕疙瘩和增生性瘢痕。
Keloids and hypertrophic scars occur anywhere from 30 to 90% of patients, and are characterized by pathologically excessive dermal fibrosis and aberrant wound healing. Both entities have different clinical and histochemical characteristics, and unfortunately still represent a great challenge for clinicians due to lack of efficacious treatments. Current advances in molecular biology and genetics reveal new preventive and therapeutical options which represent a hope to manage this highly prevalent, chronic and disabling problem, with long-term beneficial outcomes and improvement of quality of life. While we wait for these translational clinical products to be marketed, however, it is imperative to know the basics of the currently existing wide array of strategies to deal with excessive scars: from the classical corticotherapy, to the most recent botulinum toxin and lasers. The main aim of this review paper is to offer a useful up-to-date guideline to prevent and treat keloids and hypertrophic scars.
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影响因子：
2.4
作者：
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通讯作者：
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DOI：
10.1097/00004630-199509000-00002
发表时间：
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期刊：
Journal of Burn Care and Rehabilitation
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