Anxiety, depression, stress, and cortisol levels in mothers of children undergoing maintenance therapy for childhood acute lymphoblastic leukemia.
Anxiety, depression, stress, and cortisol levels in mothers of children undergoing maintenance therapy for childhood acute lymphoblastic leukemia.
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DOI：
10.1177/1043454213520346
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Laudenslager ML
中科院分区：
文献类型：
--
作者：
Neu M;Matthews E;King NA;Cook PF;Laudenslager ML
本研究的目的是比较急性淋巴细胞白血病（ALL）维持治疗期间儿童的母亲与匹配对照组之间的焦虑、抑郁和压力。从儿童医院血液科招募了26名母亲，从社区招募了26名母亲。参与者与他们孩子的年龄和性别相匹配。母亲完成医院焦虑和抑郁量表，知觉压力销售，并收集唾液皮质醇，每天4次，连续3天。与健康儿童的母亲相比，ALL儿童的母亲的焦虑评分没有差异（P = .10），但抑郁评分较高（P = .003）。ALL组中更多的母亲得分高于7分，表明临床焦虑（46%）和抑郁症状（27%）。在ALL组的母亲中发现了压力增加的趋势。在每日皮质醇总量（曲线下面积）、皮质醇每日下降量（斜率）和皮质醇觉醒反应方面没有发现差异。ALL儿童的母亲在初步诊断后数月出现情绪症状。
The purpose of this study was to compare anxiety, depression, and stress between mothers of children during maintenance treatment for acute lymphoblastic leukemia (ALL) and matched controls. Twenty-six mothers were recruited from the hematology unit at a children’s hospital, and 26 mothers were recruited from the community. Participants were matched to their child’s age and gender. Mothers completed the Hospital Anxiety and Depression Scale, the Perceived Stress Sale, and collected salivary cortisol 4 times a day for 3 consecutive days. Compared with mothers of healthy children, anxiety scores did not differ (P = .10), but depression scores were higher (P = .003) in mothers of children with ALL. More mothers in the ALL group scored above the cutoff of 7 indicating clinical anxiety (46%) and depressive symptoms (27%). A trend toward increased stress was found in mothers in the ALL group. No difference was found in overall daily cortisol (area under the curve), daily decrease in cortisol (slope), and cortisol awakening response. Mothers of children with ALL experienced emotional symptoms many months after the initial diagnosis.
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