Increased levels of circulating IL-16 and apoptosis markers are related to the activity of Whipple's disease.
Increased levels of circulating IL-16 and apoptosis markers are related to the activity of Whipple's disease.
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DOI：
10.1371/journal.pone.0000494
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发表时间：
2007-06-06
期刊：
影响因子：
3.7
通讯作者：
Mege JL
中科院分区：
文献类型：
--
作者：
Benoit M;Fenollar F;Raoult D;Mege JL
维普莱病（Whipple's disease，WD）是由惠普尔滋养体（Tropheryma whipplei）引起的一种传染性疾病。惠普尔滋养体在巨噬细胞中复制，诱导巨噬细胞释放半胱天冬酶3（caspase 3）的底物白细胞介素（IL）-16，并诱导巨噬细胞凋亡。该疾病的特征是肠道，心脏或神经系统的表现;其诊断是基于侵入性分析，需要组织活检或脑脊液穿刺。疾病进展缓慢，尽管经验性抗生素治疗，但经常复发。我们监测了36例法国WD患者的IL-16和核小体循环水平，其中一些患者参加了纵向随访。与对照受试者相比，IL-16和核小体的循环水平在表现为肠道、心脏或神经系统表现的WD的未经治疗的患者中增加。这一发现是WD特有的，因为IL-16和核小体的循环水平在不相关的炎症性疾病（如炎症性肠病或Q热心内膜炎）患者中没有增加。我们还发现IL-16和核小体水平的增加与疾病的活动有关。事实上，成功的抗生素治疗将这些水平降低到对照组的水平。相比之下，复发患者的IL-16和核小体循环水平与未治疗患者一样高。在WD中，IL-16和核小体的循环水平均增加。这一发现为WD的诊断和预后提供了简单和非侵入性的工具。
Whipple's disease (WD) is an infectious disease caused by Tropheryma whipplei, which replicates in macrophages and induces the release of interleukin (IL)-16, a substrate of caspase 3, and macrophage apoptosis. The disease is characterized by intestinal, cardiac or neurological manifestations; its diagnosis is based on invasive analysis requiring tissue biopsies or cerebrospinal fluid puncture. The disease progression is slow and often complicated by relapses despite empirical antibiotic treatment. We monitored circulating levels of IL-16 and nucleosomes in 36 French patients with WD; among them, some patients were enrolled in a longitudinal follow-up. As compared to control subjects, the circulating levels of both IL-16 and nucleosomes were increased in untreated patients with WD presenting as intestinal, cardiac or neurological manifestations. This finding was specific to WD since the circulating levels of IL-16 and nucleosomes were not increased in patients with unrelated inflammatory diseases such as inflammatory bowel disease or Q fever endocarditis. We also found that increased levels of IL-16 and nucleosomes were related to the activity of the disease. Indeed, successful antibiotic treatment decreased those levels down to those of control subjects. In contrast, patients who suffered from relapses exhibited circulating levels of IL-16 and nucleosomes as high as those of untreated patients. Circulating levels of both IL-16 and nucleosomes were increased in WD. This finding provides simple and non-invasive tools for the diagnosis and the prognosis of WD.
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通讯作者：
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