Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies.
Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies.
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DOI：
10.1186/s12888-014-0321-9
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发表时间：
2014-11-19
期刊：
影响因子：
4.4
通讯作者：
Bramon E
中科院分区：
文献类型：
--
作者：
Su L;Cai Y;Xu Y;Dutt A;Shi S;Bramon E
重性抑郁症（MDD）是一种常见的精神疾病，终生患病率接近20%。正电子发射断层扫描（PET）研究报告，与健康对照组相比，抑郁症患者的前额叶、岛叶和边缘脑葡萄糖代谢降低。然而，文献并不总是一致的。为了评价PET研究的现有证据，我们对MDD患者的脑代谢进行了基于体素的荟萃分析。数据收集自PubMed和Web of Science等数据库，最新报告截至2013年4月。使用修订的激活似然估计（ALE）软件进行基于体素的荟萃分析。10项基于全脑的MDD FDG-PET研究纳入荟萃分析，包括188例MDD患者和169例健康对照。ALE分析显示，双侧延髓、左侧豆状核、核外、右侧尾状核和扣带回的脑代谢明显降低。而MDD患者右丘脑枕、后叶下降、左前叶蚓部峰的脑电活动明显增加。我们的荟萃分析表明，特定的大脑区域，可能的功能障碍更一致地报告在MDD患者。脑、边缘系统、基底神经节、丘脑和小脑的代谢改变，因此这些区域可能在抑郁症的病理生理学中起关键作用。
Major depressive disorder (MDD) is a common mental illness with high lifetime prevalence close to 20%. Positron emission tomography (PET) studies have reported decreased prefrontal, insular and limbic cerebral glucose metabolism in depressed patients compared with healthy controls. However, the literature has not always been consistent. To evaluate current evidence from PET studies, we conducted a voxel-based meta-analysis of cerebral metabolism in MDD. Data were collected from databases including PubMed and Web of Science, with the last report up to April 2013. Voxel-based meta-analyses were performed using the revised activation likelihood estimation (ALE) software. Ten whole-brain-based FDG-PET studies in MDD were included in the meta-analysis, comprising 188 MDD patients and 169 healthy controls. ALE analyses showed the brain metabolism in bilateral insula, left lentiform nucleus putamen and extra-nuclear, right caudate and cingulate gyrus were significantly decreased. However, the brain activity in right thalamus pulvinar and declive of posterior lobe, left culmen of vermis in anterior lobe were significantly increased in MDD patients. Our meta-analysis demonstrates the specific brain regions where possible dysfunctions are more consistently reported in MDD patients. Altered metabolism in insula, limbic system, basal ganglia, thalamus, and cerebellum and thus these regions are likely to play a key role in the pathophysiology of depression.
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影响因子：
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作者：
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