Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates.
Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates.
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DOI：
10.1016/j.neubiorev.2008.09.001
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发表时间：
2009-04
影响因子：
8.2
通讯作者：
Suomi, Stephen J.
中科院分区：
文献类型：
--
作者：
Cirulli, Francesca;Francia, Nadia;Berry, Alessandra;Aloe, Luigi;Alleva, Enrico;Suomi, Stephen J.
关键词：
早期不良事件可以增强压力反应能力，并导致成年后更容易患精神病理学。将饲养环境的特定特征转化为大脑和行为可塑性的稳定变化所涉及的表观遗传因素才刚刚开始被阐明。神经营养因子，如神经生长因子（NGF）和脑源性神经营养因子（BDNF），受到压力的影响，在大脑发育以及涉及认知功能和情绪障碍的特定神经元网络的营养中发挥着重要作用。除了中枢神经系统之外，这些效应器是由周围组织产生的，因此能够整合对外部挑战的反应。在本文中，我们将回顾从动物模型获得的数据，这些数据表明早期母亲剥夺压力会影响神经营养蛋白水平，表明它们可能参与母婴关系的潜在机制。出生后早期 NGF 和 BDNF 的适应不良或反复激活可能会影响成年期的压力敏感性，并增加与压力相关的精神病理学的脆弱性。
Early adverse events can enhance stress responsiveness and lead to greater susceptibility for psychopathology at adulthood. The epigenetic factors involved in transducing specific features of the rearing environment into stable changes in brain and behavioral plasticity have only begun to be elucidated. Neurotrophic factors, such as Nerve Growth Factor (NGF) and Brain-derived neurotrophic factor (BDNF), are affected by stress and play a major role in brain development and in the trophism of specific neuronal networks involved in cognitive function and in mood disorders. In addition to the central nervous system, these effectors are produced by peripheral tissues, thus being in a position to integrate the response to external challenges. In this paper we will review data, obtained from animal models, indicating that early maternal deprivation stress can affect neurotrophin levels, suggesting that they might be involved in the mechanisms underlying the mother-infant relationship. Maladaptive or repeated activation of NGF and BDNF, early during postnatal life, may influence stress sensitivity at adulthood and increase vulnerability for stress-related psychopathology.
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影响因子：
8.2
作者：
Cirulli, F;Berry, A;Alleva, E
通讯作者：
Alleva, E
影响因子：
3.6
作者：
Cirulli, F;Micera, A;Aloe, L
通讯作者：
Aloe, L
影响因子：
4.2
作者：
Branchi, I;D'Andrea, I;Alleva, E
通讯作者：
Alleva, E
影响因子：
3.3
作者：
BOWLBY, J
通讯作者：
BOWLBY, J
DOI：
10.1073/pnas.83.16.6184
发表时间：
1986-08-01
影响因子：
11.1
作者：
ALOE, L;ALLEVA, E;LEVIMONTALCINI, R
通讯作者：
LEVIMONTALCINI, R