Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
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DOI：
10.1002/nbm.2913
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发表时间：
2013-06
影响因子：
2.9
通讯作者：
Ronca, April E.
中科院分区：
文献类型：
--
作者：
Morgan, Jonathan J.;Kleven, Gale A.;Tulbert, Christina D.;Olson, John;Horita, David A.;Ronca, April E.
本研究代表了对跨越婴儿期、青春期和成年早期发育中的大鼠大脑的第一个纵向、受试者内 1H MRS 研究。我们在出生后第 7 天、第 35 天和第 60 天，从位于前脑中央位置（以纹状体为中心）的体素中获得了神经代谢物谱，对皮质、丘脑和下丘脑的贡献较小。对水标度代谢物信号进行 T1 效应校正，并使用自动处理软件 LCModel 进行量化，产生摩尔浓度。我们的研究结果表明，N-乙酰天冬氨酸+N-乙酰天冬氨酰谷氨酸、肌醇、谷氨酸+谷氨酰胺、牛磺酸、肌酸+磷酸肌酸和甘油磷酸胆碱+磷酸胆碱的浓度变化与年龄相关。通过重复测量设计和分析，我们确定了所有三个发育年龄的显着神经发育变化，并将青春期确定为规范神经代谢大脑发育的独特阶段。在出生后 35 天至 60 天之间，观察到出生后 35 天至 60 天之间观察到的 N-乙酰天冬氨酸 + N-乙酰天冬氨酰谷氨酸、谷氨酸 + 谷氨酰胺和甘油磷酸胆碱 + 磷酸胆碱浓度的变化。我们的数据复制了过去对早期神经代谢物发育的研究，并首次将同一受试者在婴儿期、青春期和成年期的成熟概况联系起来。
The present study represents the first longitudinal, within-subject 1H MRS investigation of the developing rat brain spanning infancy, adolescence, and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location of the forebrain, centered on the striatum, with smaller contributions for cortex, thalamus, and hypothalamus, on postnatal days 7, 35, and 60. Water-scaled metabolite signals were corrected for T1 effects and quantified using the automated processing software LCModel, yielding molal concentrations. Our findings indicate age-related concentration changes in N-acetylaspartate + N-acetylaspartylglutamate, myo-inositol, glutamate + glutamine, taurine, creatine + phosphocreatine, and glycerophosphocholine + phosphocholine. Using a repeated measures design and analysis, we identified significant neurodevelopment change across all three developmental ages and identified adolescence as a distinctive phase in normative neurometabolic brain development. Between postnatal days 35 and 60, changes were observed in concentrations of N-acetylaspartate + N-acetylaspartylglutamate, glutamate + glutamine, and glycerophosphocholine + phosphocholine observed between postnatal days 35 and 60. Our data replicate past studies of early neurometabolite development and, for the first time, link maturational profiles in the same subjects across infancy, adolescence, and adulthood.
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影响因子：
3.3
作者：
Du, Fei;Zhang, Yi;Iltis, Isabelle;Marjanska, Malgorzata;Zhu, Xiao-Hong;Henry, Pierre-Gilles;Chen, Wei
通讯作者：
Chen, Wei
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BURRI, R;BIGLER, P;HERSCHKOWITZ, N
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HERSCHKOWITZ, N
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通讯作者：
WELLS, WW
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作者：
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通讯作者：
Finlay, Barbara L.
影响因子：
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作者：
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通讯作者：
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