Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective.

Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective.
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DOI:
10.1038/nrn3524
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发表时间:
2013-07
影响因子:
34.7
通讯作者:
Nitschke, Jack B.
Nitschke, Jack B.
中科院分区:
医学1区
文献类型:
--
作者:
Grupe, Dan W.;Nitschke, Jack B.

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对未来可能的威胁的不确定性扰乱了我们避免或减轻其负面影响的能力,从而导致焦虑。在这里,我们通过不确定性的镜头,关注焦虑的神经生物学方面的广泛文献。我们确定了对未来威胁不确定性的适应性预期反应所必需的五个过程,并提出这些过程的神经实例化的改变会导致对病理性焦虑中的不确定性的不良适应反应。这一框架有可能推进临床焦虑症的分类、诊断和治疗。
Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its negative impact, and thus results in anxiety. Here, we focus the broad literature on the neurobiology of anxiety through the lens of uncertainty. We identify five processes essential for adaptive anticipatory responses to future threat uncertainty, and propose that alterations to the neural instantiation of these processes results in maladaptive responses to uncertainty in pathological anxiety. This framework has the potential to advance the classification, diagnosis, and treatment of clinical anxiety.
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