Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective.
Uncertainty and anticipation in anxiety: an integrated neurobiological and psychological perspective.
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DOI:
10.1038/nrn3524
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发表时间:
2013-07
影响因子:
34.7
通讯作者:
Nitschke, Jack B.
中科院分区:
文献类型:
--
作者:
Grupe, Dan W.;Nitschke, Jack B.
Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its negative impact, and thus results in anxiety. Here, we focus the broad literature on the neurobiology of anxiety through the lens of uncertainty. We identify five processes essential for adaptive anticipatory responses to future threat uncertainty, and propose that alterations to the neural instantiation of these processes results in maladaptive responses to uncertainty in pathological anxiety. This framework has the potential to advance the classification, diagnosis, and treatment of clinical anxiety.
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