Biphasic ferrogels for triggered drug and cell delivery.
Biphasic ferrogels for triggered drug and cell delivery.
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DOI：
10.1002/adhm.201400095
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发表时间：
2014-11
影响因子：
10
通讯作者：
Mooney, David J.
中科院分区：
文献类型：
--
作者：
Cezar, Christine A.;Kennedy, Stephen M.;Mehta, Manav;Weaver, James C.;Gu, Luo;Vandenburgh, Herman;Mooney, David J.
由于其能够按需提供多种治疗药物，因此对许多生物医学应用而言是一种极具吸引力的材料。然而，典型的铁蛋白在基于细胞的治疗中的使用还有待优化，因为它们拥有有限的藏匿和释放活细胞的能力。此前，我们已经展示了一种活性多孔支架，它在中等磁场下表现出大的变形，从而增强了生物制剂的释放。然而，在最适合植入的小器件尺寸(例如，2 mm厚度)下，由于体力降低，这些单相铁氧体不再实现显著的变形。在这项研究中，我们提出了一种新的两相铁凝胶，含有氧化铁梯度，即使在小的凝胶尺寸下也能产生大的变形并触发释放。双相铁氧体由于其氧化铁含量的减少，表现出更高的孔隙率，增强的机械性能，并潜在地提高了生物相容性。由于它们能够按需输送药物和细胞，预计这些铁蛋白将在组织工程和再生医学领域具有广泛的用途。
Ferrogels are an attractive material for many biomedical applications due to their ability to deliver a wide variety of therapeutic drugs on-demand. However, typical ferrogels have yet to be optimized for use in cell-based therapies, as they possess limited ability to harbor and release viable cells. Previously, we have demonstrated an active porous scaffold that exhibits large deformations under moderate magnetic fields, resulting in enhanced biological agent release. However, at small device sizes optimal for implantation (e.g., 2 mm thickness), these monophasic ferrogels no longer achieve significant deformation due to a reduced body force. In this study, we present a new biphasic ferrogel containing an iron oxide gradient capable of large deformations and triggered release even at small gel dimensions. Biphasic ferrogels demonstrate increased porosity, enhanced mechanical properties, and potentially increased biocompatibility due to their reduced iron oxide content. With their ability to deliver drugs and cells on-demand, it is expected that these ferrogels will have wide utility in the fields of tissue engineering and regenerative medicine.
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影响因子：
5.5
作者：
Hu, Shang-Hsiu;Liu, Ting-Yu;Chen, San-Yuan
通讯作者：
Chen, San-Yuan
影响因子：
2.5
作者：
Mendoza Zelis, P.;Muraca, D.;Sanchez, F. H.
通讯作者：
Sanchez, F. H.
影响因子：
3.9
作者：
Liu, Ting-Yu;Hu, Shang-Hsiu;Chen, San-Yuan
通讯作者：
Chen, San-Yuan
影响因子：
10.8
作者：
Liu, Ting-Yu;Hu, Shang-Hsiu;Chen, San-Yuan
通讯作者：
Chen, San-Yuan
影响因子：
6.1
作者：
Hong, Sungmin;Jung, Youngmee;Zhao, Xuanhe
通讯作者：
Zhao, Xuanhe