Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine cervical cancers.
Expression of platelet-derived endothelial cell growth factor (PD-ECGF) and its mRNA in uterine cervical cancers.
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DOI：
10.1038/sj.bjc.6690200
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发表时间：
1999-03
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
血管生成有助于实体瘤的生长和继发性扩散。血小板衍生的内皮细胞生长因子（PD-ECGF）被鉴定为这样的血管生成因子。在本研究中，高PD-ECGF宫颈癌患者的预后比低PD-ECGF宫颈癌患者差，PD-ECGF表达与宫颈癌中的细胞增殖、血管密度和静脉浸润相关。因此，PD-ECGF可能通过与血管扩散相关的血管生成促进宫颈癌的生长。此外，PD-ECGF及其mRNA在宫颈癌中的表达范围较广，且无论临床分期如何，其在宫颈癌尤其是鳞状细胞癌中均呈高表达。因此，PD-ECGF在宫颈癌的发生发展过程中可能发挥着基础性血管生成的作用。这表明5′-脱氧-5-氟尿嘧啶对宫颈鳞状细胞癌可能是非常有效的，它具有高活性的胸苷磷酸化酶将5′-脱氧-5-氟尿嘧啶转化为5-氟尿嘧啶，并且一些新的毛细血管形成的血管生成抑制剂可能有效地抑制肿瘤生长和与血管生成相关的扩散。© 1999癌症研究运动
Angiogenesis contributes to the growth and secondary spreading of solid tumours. Platelet-derived endothelial cell growth factor (PD-ECGF) is identified as such an angiogenic factor. In the present study, the prognosis of the patients with high PD-ECGF uterine cervical cancers was worse than those with low PD-ECGF cancers, and PD-ECGF expression correlated with cellular proliferation and with vascular density and venous invasion in uterine cervical cancers. Therefore, PD-ECGF might contribute to the growth of uterine cervical cancers via angiogenesis related to vascular spreading. Furthermore, PD-ECGF and its mRNA had a wide range and were highly expressed in uterine cervical cancers, especially squamous cell carcinoma, regardless of clinical stage. Therefore, PD-ECGF in uterine cervical cancers might play a role of basic angiogenesis in all processes of advancing of uterine cervical cancers. This indicates that 5′-deoxy-5-fluorouridine might be highly effective in squamous cell carcinoma of the cervix, which possesses a high activity of thymidine phosphorylase to convert 5′-deoxy-5-fluorouridine to 5-fluorouracil, and that some angiogenic inhibitors of new capillary formation might be effective in the inhibition of tumour growth and spreading associated with angiogenesis. © 1999 Cancer Research Campaign
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影响因子：
14.9
作者：
ARCARI, P;MARTINELLI, R;SALVATORE, F
通讯作者：
SALVATORE, F
影响因子：
2.9
作者：
CHOMCZYNSKI, P;SACCHI, N
通讯作者：
SACCHI, N
影响因子：
9.7
作者：
Fujimoto, J;Ichigo, S;Tamaya, T
通讯作者：
Tamaya, T
胸苷磷酸化酶/血小板衍生的内皮细胞生长因子表达与胃癌中的肝转移相关。
影响因子：
8.8
作者：
Maeda, K;Chung, Y S;Ogawa, Y;Takatsuka, S;Kang, S M;Ogawa, M;Sawada, T;Onoda, N;Kato, Y;Sowa, M
通讯作者：
Sowa, M
影响因子：
4
作者：
Fujimoto, J;Ichigo, S;Tamaya, T
通讯作者：
Tamaya, T