Cross-sectional study examining household factors associated with SARS-CoV-2 seropositivity in low-income children in Los Angeles.
Cross-sectional study examining household factors associated with SARS-CoV-2 seropositivity in low-income children in Los Angeles.
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DOI：
10.1136/bmjopen-2022-070291
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发表时间：
2023-05-31
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
这项研究旨在量化洛杉矶服务不足的拉美裔人口受到SARS-CoV-2影响的程度，并确定与儿科血清阳性相关的因素。横截面。AltaMed是一家位于洛杉矶的联邦合格健康中心。在AltaMed医疗集团接受医疗保健的家庭中，随机抽样的家庭被邀请参加。至少有一名成人和一名5至17岁的儿科参与者的家庭有资格参加。征得同意的参与者完成了一项关于健康的社会决定因素的调查，并使用雅培建筑师SARS-CoV-2-IgG和SARS-CoV-2-IgM测试了抗体。血清呈阳性状态。我们分析了196个家庭的390名成年人(平均年龄38.98岁(SD 12.11))和332名儿科参与者(11.26岁(SD 3.51))。儿科受试者的估计血清阳性率为52.11%(95%可信区间为49.61%~55.19%)，成人为63.58%(95%可信区间为60.39%~65.24%)。儿科患者的血清阳性率较低11.47%(95%可信区间为6.82%~14.09%)，但高于其他人群。有2型糖尿病的家庭成员(OR 2.94(95%CI 1.68~5.14))、领取食品券(OR 1.66(95%CI 1.08~2.56))和户主教育程度低(OR 1.73(95%CI 1.06~2.84))与儿科血清阳性有关。在洛杉矶的西班牙裔儿童和青少年中，SARS-CoV-2血清阳性率很高。食物不安全的家庭，户主教育程度低，以及至少有一名家庭成员患有2型糖尿病，风险最高。这些因素可能会为儿科医生提出新冠肺炎缓解建议。NCT04901624。
This study aims to quantify the degree to which an underserved, Hispanic population in Los Angeles is impacted by SARS-CoV-2, and determine factors associated with paediatric seropositivity. Cross-sectional. AltaMed, a Federally Qualified Health Center in Los Angeles. A random sample of households who had received healthcare at AltaMed Medical Group was invited to participate. Households with at least one adult and one paediatric participant between 5 and 17 years of age were eligible to participate. Consented participants completed a survey on social determinants of health and were tested for antibodies using Abbott Architect SARS-CoV-2-IgG and SARS-CoV-2-IgM tests. Seropositive status. We analysed 390 adults (mean age in years, 38.98 (SD 12.11)) and 332 paediatric participants (11.26 (SD 3.51)) from 196 households. Estimated seropositivity was 52.11% (95% CI 49.61% to 55.19%) in paediatric participants and 63.58% (95% CI 60.39% to 65.24%) in adults. Seropositivity was 11.47% (95% CI 6.82% to 14.09%) lower in paediatric participants, but high relative to other populations. A household member with type 2 diabetes (OR 2.94 (95% CI 1.68 to 5.14)), receipt of food stamps (OR 1.66 (95% CI 1.08 to 2.56)) and lower head-of-household education (OR 1.73 (95% CI 1.06 to 2.84)) were associated with paediatric seropositivity. SARS-CoV-2 seropositivity is high in Hispanic children and adolescents in Los Angeles. Food insecure households with low head-of-household education, and at least one household member with type 2 diabetes, had the highest risk. These factors may inform paediatrician COVID-19 mitigation recommendations. NCT04901624.
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影响因子：
3.7
作者：
Chen YH;Glymour M;Riley A;Balmes J;Duchowny K;Harrison R;Matthay E;Bibbins-Domingo K
通讯作者：
Bibbins-Domingo K
影响因子：
26.1
作者：
Tönshoff B;Müller B;Elling R;Renk H;Meissner P;Hengel H;Garbade SF;Kieser M;Jeltsch K;Grulich-Henn J;Euler J;Stich M;Chobanyan-Jürgens K;Zernickel M;Janda A;Wölfle L;Stamminger T;Iftner T;Ganzenmueller T;Schmitt C;Görne T;Laketa V;Olberg S;Plaszczyca A;Cortese M;Bartenschlager R;Pape C;Remme R;Huzly D;Panning M;Weigang S;Giese S;Ciminski K;Ankerhold J;Kochs G;Schwemmle M;Handgretinger R;Niemeyer CM;Engel C;Kern WV;Hoffmann GF;Franz AR;Henneke P;Debatin KM;Kräusslich HG
通讯作者：
Kräusslich HG
影响因子：
2
作者：
Toubat, Omar;Berg, Anders H.;Sood, Neeraj
通讯作者：
Sood, Neeraj
影响因子：
12
作者：
Tirupathi R;Muradova V;Shekhar R;Salim SA;Al-Tawfiq JA;Palabindala V
通讯作者：
Palabindala V
影响因子：
11.8
作者：
Stich M;Elling R;Renk H;Janda A;Garbade SF;Müller B;Kräusslich HG;Fabricius D;Zernickel M;Meissner P;Huzly D;Grulich-Henn J;Haddad A;Görne T;Spielberger B;Fritsch L;Nieters A;Hengel H;Dietz AN;Stamminger T;Ganzenmueller T;Ruetalo N;Peter A;Remppis J;Iftner T;Jeltsch K;Waterboer T;Franz AR;Hoffmann GF;Engel C;Debatin KM;Tönshoff B;Henneke P
通讯作者：
Henneke P