Detection of microspheres in vivo using multispectral optoacoustic tomography.
Detection of microspheres in vivo using multispectral optoacoustic tomography.
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DOI:
10.1080/10520295.2016.1251611
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发表时间:
2017
期刊:
影响因子:
--
通讯作者:
McNally LR
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文献类型:
--
作者:
Bhutiani N;Kimbrough CW;Burton NC;Morscher S;Egger M;McMasters K;Woloszynska-Read A;El-Baz A;McNally LR
We introduce a new approach to detect individual microparticles that contain NIR fluorescent dye by multispectral optoacoustic tomography in the context of the hemoglobin-rich environment within murine liver. We encapsulated a near infrared (NIR) fluorescent dye within polystyrene microspheres, then injected them into the ileocolic vein, which drains to the liver. NIR absorption was determined using multispectral optoacoustic tomography. To quantitate the minimum diameter of microspheres, we used both colorimetric and spatial information to segment the regions in which the microspheres appear. Regional diameter was estimated by doubling the maximum regional distance. We found that the minimum microsphere size threshold for detection by multispectral optoacoustic tomography images is 78.9 µm.
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DOI:
10.1158/1078-0432.ccr-16-0573
发表时间:
2016-07-15
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
作者:
McNally LR;Mezera M;Morgan DE;Frederick PJ;Yang ES;Eltoum IE;Grizzle WE
通讯作者:
Grizzle WE
DOI:
10.1158/1078-0432.ccr-15-0314
发表时间:
2015-10-15
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
作者:
Kimbrough CW;Khanal A;Zeiderman M;Khanal BR;Burton NC;McMasters KM;Vickers SM;Grizzle WE;McNally LR
通讯作者:
McNally LR
影响因子:
10.6
作者:
Farag, AA;El-Baz, AS;Gimel'farb, G
通讯作者:
Gimel'farb, G
影响因子:
3.5
作者:
Ermilov, Sergey A.;Khamapirad, Tuenchit;Oraevsky, Alexander A.
通讯作者:
Oraevsky, Alexander A.
影响因子:
10.3
作者:
GOLDROSEN, MH;PAOLINI, N;HOLYOKE, ED
通讯作者:
HOLYOKE, ED